Phenotypic Switching

Implications in Biology and Medicine

Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Vidyanand Nanjundiah

• Publisher: Academic Press
• Year: 2020
• Print ISBN:
  9780128179963
• eBook ISBN:
  9780128179970
• Topic: Medicine
• Subtopic: Genetics in Medicine

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. - Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity - Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies - Features a diverse range of chapter contributions from international leaders in the field

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• List of contributors
• Preface: Early thoughts on phenotypic plasticity in development and evolution
• Summaries of contributions
• Acknowledgments
• 1. The fundamentals of phenotypic plasticity
• 2. Rethinking the role of chance in the explanation of cell differentiation
• 3. Random walk across the epigenetic landscape
• 4. Manoeuvring protein functions and functional levels by structural excursions
• 5. Prion-mediated phenotypic diversity in fungi
• 6. Bistability in virus–host interaction networks underlies the success of hepatitis C treatments
• 7. Quantifying Waddington landscapes, paths, and kinetics of cell fate decision making of differentiation/development
• 8. The physics of cell fate
• 9. Disentangling the environmentally induced and stochastic developmental components of phenotypic variation
• 10. The evolution of cell differentiation in animals: biomolecular condensates as amplification hubs of inherent cell functions
• 11. Phenotypic switching and its evolutionary consequences
• 12. Cell-state organization by exploratory sloppy dynamics
• 13. Emergence of metabolic heterogeneity in cell populations: lessons from budding yeast
• 14. Stochastic phenotypic switching in endothelial cell heterogeneity
• 15. Regulation of phenotypic plasticity from the perspective of evolutionary developmental biology
• 16. Phenotypic plasticity and the origins of novelty
• 17. Niche construction and the transition to herbivory: Phenotype switching and the organization of new nutritional modes
• 18. Nature, nurture, and noise in bird song ontogeny as determinants of phenotypic and functional variation among dialects
• 19. Domestication as a process generating phenotypic diversity
• 20. The glycobiology of ovarian cancer progression: phenotypic switches and microenvironmental influences
• 21. Epithelial-mesenchymal transition in cancer
• 22. Phenotypic switching and prostate diseases: a model proposing a causal link between benign prostatic hyperplasia and prostate cancer
• 23. Phenotypic plasticity and lineage switching in prostate cancer
• 24. Implications of non-genetic heterogeneity in cancer drug resistance and malignant progression
• 25. Phenotypic plasticity: the emergence of cancer stem cells and collective cell migration
• 26. Adaptive phenotypic switching in breast cancer in response to matrix deprivation
• 27. Phenotypic instability induced by tissue disruption at the origin of cancer
• 28. Evolutionary strategies to overcome cancer cell resistance to treatment
• Index