Strategies and Tactics in Organic Synthesis

Michael Harmata

• Publisher: Elsevier
• Year: 2015
• Print ISBN:
  9780081000236
• eBook ISBN:
  9780081000465
• Topic: Technology & Engineering
• Subtopic: Organic Chemistry
• Index: Technology & Engineering

Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world. - Presents state-of-the-art developments in organic synthesis - Provides insight and offers new perspective to problem-solving - Written by leading experts in the field - Uses firsthand narrative accounts to illustrate vividly the challenges and joys involved in advancing the science of organic synthesis

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• Contributors
• Preface
• Chapter 1: Acortatarin A: Spiroketalization Methods and Synthesis
• Chapter 2: Devising New Syntheses of the Alkaloid Galanthamine, a Potent and Clinically Deployed Inhibitor of Acetylcholine Esterase
• Chapter 3: Discodermolide: Total Synthesis of Natural Product and Analogues
• Chapter 4: A Walk Across Africa with Captain Grant: Exploring Mycobacterium ulcerans Infection with Mycolactone Analogs
• Chapter 5: Total Synthesis of the Fungal Metabolite Virgatolide B
• Chapter 6: The Role of Design, Serendipity, and Scientific Competition in the Development of Oxidative Coupling Reactions
• Chapter 7: Overcoming Electronics with Strategy: Development of an Efficient Synthesis of the HIV Attachment Inhibitor Prodrug, BMS-663068
• Chapter 8: Synthesis of Alkaloids Containing a Quinolizidine Core by Means of Strategies Based on a Hydroformylation Reaction
• Chapter 9: Total Synthesis of Sorbicillactone A: An Inspiration for Methodology and Catalyst Development
• Chapter 10: Total Synthesis of (−)-7-Deoxyloganin Exploiting N-Heterocyclic Carbene Catalysis with α,β-Unsaturated Enol Esters
• Chapter 11: The Realization of an Oxidative Dearomatization–Intramolecular Diels–Alder Route to Vinigrol
• Chapter 12: Total Synthesis of Communesin F and Perophoramidine
• Index