Strategies and Tactics in Organic Synthesis

Michael Harmata

• Publisher: Academic Press
• Year: 2004
• Print ISBN: 9780124502833
• eBook ISBN: 9780080517964
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.- Personal accounts of research in organic chemistry. - Written by internationally renowned scientists.- Details state of the art organic synthesis.

Table of contents

• Cover image
• Title page
• Table of Contents
• Front Matter
• Copyright page
• Contributors
• Dedication
• Foreword
• Preface
• Chapter 1: Methodology Validation and Structure Correction by Total Synthesis: The Case of the Clerodane Diterpenoid, Sacacarin
• Chapter 2: Total Synthesis of (±)-Cylindrospermopsin
• Chapter 3: The Total Synthesis of (-)-Arisugacin A.
• Chapter 4: Total Synthesis of Kainoids by Dearomatizing Anionic Cyclization
• Chapter 5: Total Synthesis of Jatrophatrione, an Unprecedented [5.9.5] Tricyclic Antileukemic Diterpene
• Chapter 6: Alkynyliodonium Salts in Organic Synthesis
• Chapter 7: How to Thread a String Through the Eye of a Molecular Needle: Template Synthesis of Interlocked Molecules
• Chapter 8: Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols
• Chapter 9: The Ring-Closing Metathesis Approach to Fumagillol
• Chapter 10: Devising An Especially Efficient Route to the ‘Miracle’ Nutrient Coenzyme Q10
• Chapter 11: Total Synthesis of Lipid I and Lipid II: Late-Stage Intermediates Utilized in Bacterial Cell Wall Biosynthesis
• Chapter 12: Ring Rearrangement Metathesis (RRM) – A New Concept in Piperidine and Pyrrolidine Synthesis
• Chapter 13: Catalytic Asymmetric Total Synthesis of (−)-Strychnine and Fostriecin
• Chapter 14: The Synthesis of (±)-Strychnine VIA A Cobalt-Mediated [2 + 2 + 2] Cyclo Addition
• Index