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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Georg Hempel
- 380 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Georg Hempel
About This Book
Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.
- Presents a unique, interdisciplinary approach that appeals to a wide range of users
- Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments
- Features additional therapeutic drugs to reflect the rising number of immunocompromised patients
- Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories
Frequently asked questions
Information
Sample preparation for the analysis of drugs in biological fluids
â Corresponding author.
Abstract
Keywords
1.1. Introduction
![Figure 1.1](OEBPS/IMAGES/B9780444640666000010/main.assets/f01-01-9780444640666-plgo-compressed.webp)
1.2. Conventional sample preparation for therapeutic drug analysis in biological samples
1.2.1. Protein removal and liquidâliquid extraction
Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1. Sample preparation for the analysis of drugs in biological fluids
- Chapter 2. Drug analyses in human plasma by chromatography
- Chapter 3. Mass spectrometry for the quantification of drugs in biosamples
- Chapter 4. Capillary electrophoresis for the determination of drugs in biological fluids
- Chapter 5. Immunoassays for therapeutic drug monitoring and clinical toxicology
- Chapter 6. Validation of bioanalytical chromatographic methods for the quantification of drugs in biological fluids
- Chapter 7. Pharmacokinetic methods for TDM data analysis and optimal individualization of drug dosage regimens
- Chapter 8. Therapeutic drug monitoring of antibiotics in critically ill patients
- Chapter 9. Therapeutic drug monitoring for antifungal triazoles: pharmacologic background and current status
- Chapter 10. Therapeutic monitoring of antiepileptic drugs
- Chapter 11. Therapeutic drug monitoring of antidepressant and antipsychotic drugs
- Chapter 12. Assessing immunosuppressive drug concentrations in clinical practice
- Chapter 13. Dose and therapy individualization in cancer chemotherapy
- Chapter 14. Pharmacogenomics
- Index