Human Microbiota in Health and Disease

From Pathogenesis to Therapy

Bryan Tungland

• Publisher: Academic Press
• Year: 2018
• Print ISBN: 9780128146491
• eBook ISBN: 9780128146507
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion of all the aspects associated with gut microbiota early colonization, its development and maintenance, and its symbiotic relationship with the host to promote health. Chapters illustrate the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, while mediating inflammatory processes involved in the etiology of many chronic disease conditions. Details are provided on the primary etiological factors of chronic disease, the effects of gut dysbiosis and its associated disease conditions, while providing an overview of therapeutic strategies involving dietary fiber and prebiotics, fecal microbiota transplantation therapy and probiotics. Throughout the chapters, a comprehensive review of peer-reviewed animal and human studies is provided as evidence related to the history of human exposure, safety, tolerance, toxicity, nomenclature, and clinical efficacy of utilizing prebiotic fructans, s, as well as probiotic intervention, and dietary modification in the prevention and intervention of chronic disease conditions. With common use today of pharmaceutical medicine in treating symptoms, and frequent overuse of antibiotics in chronic disease within mainstream medical practice, understanding the etiological mechanisms of dysbiosis-induced chronic disease, and natural approaches that offer prevention and potential cures for these diseases is of vital importance to overall human health. - Details the complex relationship between human microbiota in the gut, oral cavity, urogenital tract and skin as well as their colonization, development and impact of factors that influence the relationship - Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease - Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification, and pro- and pre-biotics in preventing and intervening in chronic disease

Table of contents

• Cover
• Title page
• Table of Contents
• Copyright
• Dedication
• Preface
• Chapter 1: Gut Microbiota, Early Colonization and Factors in its Development that Influence Health
• Chapter 2: Short-Chain Fatty Acid Production and Functional Aspects on Host Metabolism
• Chapter 3: Gut Microbiota Influence Lipid and Glucose Metabolism, Energy Homeostasis and Inflammation Through Effects on Bile Acid Metabolism
• Chapter 4: Role of Gut Microbiota in Immune Homeostasis
• Chapter 5: Direct Physiological Effects on Local Gi and Indirect Systemic Effects of Prebiotic Fructan Treatment, and its Role in Disease Prevention and Therapy
• Chapter 6: Intestinal-Based Diseases and Peripheral Infection Risk Associated with Gut Dysbiosis: Therapeutic use of Pre- and Probiotics and Fecal Microbiota Transplantation
• Chapter 7: Overview of Prebiotics: Membership, Physiological Effects and their Health Attributes
• Chapter 8: Nondigestible Fructans as Prebiotics
• Chapter 9: Dysbiosis of the Microbiota: Therapeutic Strategies Utilizing Dietary Modification, Pro- and Prebiotics and Fecal Transplant Therapies in Promoting Normal Balance and Local GI Functions
• Chapter 10: Oral Dysbiosis and Periodontal Disease: Effects on Systemic Physiology and in Metabolic Diseases, and Effects of Various Therapeutic Strategies
• Chapter 11: Intestinal Dysbiosis in Obesity, Metabolic Syndrome and Related Metabolic Diseases: Therapeutic Strategies Utilizing Dietary Modification, Pro- and Prebiotics, and Fecal Microbial Transplant (FMT) Therapy
• Chapter 12: Gut Microbiota in Brain Development and Disorders of the CNS: Therapeutic Strategies Involving Dietary Modification, Pro- and Prebiotic Intervention, and Fecal Microbiota Transplantation (FMT) Therapy
• Chapter 13: The Gut-Brain-Skin Axis and Role of Intestinal Dysbiosis in Acne Vulgaris: Therapeutic Effects of Pro- and Prebiotic Use
• Chapter 14: Microbiota and the Urogenital Tract, Pathogenesis, and Therapies
• Index