Translational Systems Medicine and Oral Disease

Stephen T. Sonis, Alessandro Villa, Stephen Sonis

• Publisher: Academic Press
• Year: 2019
• Print ISBN:
  9780128137628
• eBook ISBN:
  9780128137635
• Topic: Medicine
• Subtopic: Genetics in Medicine

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. - Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine - Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases - Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader - Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• List of contributors
• Preface
• 1. Introduction to systems medicine
• 2. System biology
• 3. Genomic foundation for medical and oral disease translation to clinical assessment
• 4. Proteomics
• 5. Metabolomics in head and neck cancer: A summary of findings
• 6. Microbiomics
• 7. Epigenetics and oral disease
• 8. Systems pharmacology
• 9. Functional “omics” for systems medicine
• 10. Analytic methods for systems medicine
• 11. Systems medicine and periodontal diseases
• 12. Bone translational medicine
• 13. Systems medicine and salivary gland diseases
• 14. Systems medicine, neuropathic oral diseases, and orofacial pain
• 15. Chronic systemic symptoms in cancer patients
• 16. Oral toxicities of cancer treatment
• 17. Stem cells and regenerative medicine
• 18. Translating concepts of systems medicine to the clinic
• Index