The Protective Arm of the Renin Angiotensin System (RAS)

Functional Aspects and Therapeutic Implications

Thomas Unger, U. Muscha Steckelings, Robson Augusto Souza dos Santos

• Publisher: Academic Press
• Year: 2015
• Print ISBN: 9780128013649
• eBook ISBN: 9780128014851
• Topic: Medicine
• Subtopic: Endocrinology & Metabolism

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. - Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor - Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. - Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases - Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Contributors
• Chapter 1: The Angiotensin AT2 Receptor: From Enigma to Therapeutic Target
• Chapter 2: The AT2 Receptor: Historical Perspective
• Chapter 3: Animal Models with a Genetic Alteration of AT2 Expression
• Chapter 4: AT2 Receptor Signaling: Solved and Unsolved
• Chapter 5: AT1R–AT2R Cross Talk
• Chapter 6: The Angiotensin AT2 Receptor in Myocardial Infarction
• Chapter 7: AT2R, Vascular Effects, and Blood Pressure
• Chapter 8: AT2R in Nervous System
• Chapter 9: Roles of AT2R in Cognitive Function
• Chapter 10: The Protective Role of Angiotensin II (AT2) Receptors in Renal Disease: Molecular Mechanisms and Indications for AT2 Agonist Therapy
• Chapter 11: AT2 Receptors and Natriuresis
• Chapter 12: The Role of the AT2R in Vascular Remodeling
• Chapter 13: The AT2 Receptor and Inflammation
• Chapter 14: The AT2 Receptor and Interacting Proteins (ATIPs) in Cancer
• Chapter 15: AT2R and Sympathetic Outflow
• Chapter 16: Metabolic Effects of AT2R Stimulation in Adipose Tissue
• Chapter 17: Sex Differences in AT2R Expression and Action
• Chapter 18: Discovery of Nonpeptide, Selective AT2 Receptor Agonists
• Chapter 19: Angiotensin-Based Peptides as AT2R Agonists
• Chapter 20: Potential Clinical Application of Angiotensin 2 Receptor Agonists
• Chapter 21: Angiotensin-(1-7) and Mas: A Brief History
• Chapter 22: Animal Models with a Genetic Alteration of the ACE2/Ang-(1-7)/Mas Axis
• Chapter 23: Mas Signaling: Resolved and Unresolved Issues
• Chapter 24: Mas/AT2 Cross Talk
• Chapter 25: ACE2 Cell Biology, Regulation, and Physiological Functions
• Chapter 26: Mas in Myocardial Infarction and Congestive Heart Failure
• Chapter 27: Mas Receptor: Vascular and Blood Pressure Effects
• Chapter 28: Mas and Neuroprotection in Stroke
• Chapter 29: Mas in the Kidney
• Chapter 30: Mas and Inflammation
• Chapter 31: ACE2 and Glycemic Control
• Chapter 32: Angiotensin-(1-7) and Cancer
• Chapter 33: Mas and the Central Nervous System
• Chapter 34: Role of the Alternate RAS in Liver Disease and the GI Tract
• Chapter 35: Metabolic Role of Angiotensin-(1-7)/Mas Axis
• Chapter 36: Mas and the Reproductive System
• Chapter 37: ACE2/Ang-(1-7)/Mas Axis and Physical Exercise
• Chapter 38: Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Axis: Emerging Pharmacological Target for Pulmonary Diseases
• Chapter 39: Nanocarriers for Improved Delivery of Angiotensin-(1-7)
• Chapter 40: Mas Agonists
• Chapter 41: Preclinical and Clinical Development of Angiotensin Peptides (Mas/Ang(1-7)/ACE-2): Future Clinical Application
• Index