Polymers and Nanomaterials for Gene Therapy
eBook - ePub

Polymers and Nanomaterials for Gene Therapy

  1. 302 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Polymers and Nanomaterials for Gene Therapy

About this book

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. - Explores current challenges in the research of genetic diseases - Discusses polymers for gene therapy and their function in designing advanced materials - Provides examples of organic and inorganic nanomaterials for gene therapy - Includes labeling, targeting, and assays - Looks at characterization, physico-(bio)chemical properties, and applications

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Yes, you can access Polymers and Nanomaterials for Gene Therapy by Ravin Narain in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Genetics & Genomics. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. List of Contributors
  6. Editor and Author
  7. Contributing Authors
  8. Preface
  9. 1: Mechanism, current challenges and new approaches for non viral gene delivery
  10. 2: PEI and its derivatives for gene therapy
  11. 3: Natural polymers in nucleic acid delivery
  12. 4: Synthetic cationic glycopolymers for gene delivery
  13. 5: Engineering peptide-conjugated non-viral delivery systems for enhanced SiRNA and DNA therapeutics
  14. 6: Dendrimers for gene therapy
  15. 7: Polymeric nanoparticles for gene delivery
  16. 8: Gold nanomaterials for gene therapy
  17. 9: Fabrication and development of magnetic particles for gene therapy
  18. 10: Gene therapies in clinical trials
  19. 11: Biochemical assays used for in vitro and in vivo gene expression
  20. Index