Biomarkers, Diagnostics and Precision Medicine in the Drug Industry
eBook - ePub

Biomarkers, Diagnostics and Precision Medicine in the Drug Industry

Critical Challenges, Limitations and Roadmaps for the Best Practices

  1. 294 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Biomarkers, Diagnostics and Precision Medicine in the Drug Industry

Critical Challenges, Limitations and Roadmaps for the Best Practices

About this book

The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline, as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerate the time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. This book aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies, which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. This book serves as a reference to drug developers, IVD providers, clinical labs, healthcare givers, academicians, and researchers for best practices to help increase the probability of success in drug development and improve patient management. - Provides the unique insight of an expert with extensive experience in diagnostics and clinical laboratory on one side and drug discovery and development on the other side - Addresses the challenges of drug development and precision medicine and suggests how to eliminate or mitigate these challenges through better utilization of biomarkers and diagnostics in drug development and patient management - Features case studies and real-life examples from different classes of biomarkers on different platforms for different therapeutic areas and includes more than 200 illustrations

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Information

Publisher
Academic Press
Year
2019
Print ISBN
9780128161210
eBook ISBN
9780128161227
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Dedication
  6. Preface
  7. Chapter 1. Pharmaceutical crisis
  8. Chapter 2. Applications of biomarkers for different purposes in drug development
  9. Chapter 3. Pharmacogenetics of therapeutics
  10. Chapter 4. Precision medicine and companion diagnostics in drug development
  11. Chapter 5. Essential attributes of an acceptable in vitro diagnostic test
  12. Chapter 6. Fundamentals of assay development and validation
  13. Chapter 7. Essentials of laboratory quality management
  14. Chapter 8. Biological variables and their potential impact on biomarkers and precision medicine initiative
  15. Chapter 9. Preanalytical variables and their potential impact on biomarkers and precision medicine initiative
  16. Chapter 10. Analytical discrepancies and their potential impact on biomarkers and precision medicine initiative
  17. Chapter 11. Road map to best practices
  18. Index

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Yes, you can access Biomarkers, Diagnostics and Precision Medicine in the Drug Industry by Abdel Halim in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over 1.5 million books available in our catalogue for you to explore.