Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals
Progress in Fluorine Science Series
- 686 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals
Progress in Fluorine Science Series
About this book
Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud's Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more.Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field.- Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics- Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings- Features contributions from a wealth of global experts- Acts as the fourth volume in Alain Tressaud's Progress in Fluorine Science
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Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- List of Contributors
- About the editors
- Preface
- 1. Emerging fluorination methods in organic chemistry relevant for life science application
- 2. Fluorination patterns in small alkyl groups: their impact on properties relevant to drug discovery
- 3. Polyfluorinated scaffolds in drug discovery
- 4. Case studies of fluorine in drug discovery
- 5. Recent development in fluorinated antibiotics
- 6. Fluorosugars as inhibitors of bacterial enzymes
- 7. Microbial metabolism of fluorinated drugs
- 8. Influence of fluorination on alcohol hydrogen-bond donating properties
- 9. Synthesis and applications of backbone-fluorinated amino acids
- 10. 19F-Labeled amino acids for NMR structure analysis of membrane-bound peptides
- 11. In vivo 19-fluorine magnetic resonance imaging
- 12. Fluorine-18 radiolabeling of biologics
- 13. Serotonin receptor imaging by 18F-PET
- 14. Organoboronates: captors of 18F-fluoride for one-step radiofluorination of biomolecules
- 15. Silicon-based 18F-radiopharmaceuticals: from basic SiFA chemistry toward its clinical application
- 16. Biorelevant fluorine-containing N-heterocycles
- 17. Recent applications of fluorine in crop protectionânew discoveries originating from the unique heptafluoroisopropyl group
- 18. The role of fluorine in the design of nicotinic acetylcholine receptor (nAChR) competitive modulators
- Index