Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
eBook - ePub

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volume 8- Human Diseases

  1. 418 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Volume 8- Human Diseases

About this book

Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington's disease, Parkin's disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death. - Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor, or cell death pathway, or both - Introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation - States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

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Information

Publisher
Academic Press
Year
2015
Print ISBN
9780128029374
eBook ISBN
9780128029527
Topic
Medicine
Subtopic
Immunology

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Dedication
  6. Mitophagy and Biogenesis
  7. Dedication
  8. Autophagy and Cancer
  9. Some Thoughts on Autophagy and Immunity
  10. Autophagy: Friend or Foe?
  11. Autophagy: If and When
  12. What Happened When Autophagy Didn’t
  13. Sugar Isn’t Always Sweet
  14. Mitochondrial Mysteries
  15. The Autophagy Process
  16. Foreword
  17. Foreword
  18. Preface
  19. Contributors
  20. Autophagy: Volume 1 – Contributions
  21. Autophagy: Volume 2 – Contributions
  22. Autophagy: Volume 3 – Contributions
  23. Autophagy: Volume 4 – Contributions
  24. Autophagy: Volume 5 – Contributions
  25. Autophagy: Volume 6 – Contributions
  26. Autophagy: Volume 7 – Contributions
  27. Chapter 1. Overview of Autophagy
  28. Part I: Molecular Mechanisms
  29. Part II: Role in Cell Death and Disease
  30. Part III: Role in Cancer
  31. Abbreviations and Glossary
  32. Index

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Yes, you can access Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat in PDF and/or ePUB format, as well as other popular books in Medicine & Immunology. We have over 1.5 million books available in our catalogue for you to explore.