Disease-Modifying Targets in Neurodegenerative Disorders

Paving the Way for Disease-Modifying Therapies

Veerle Baekelandt, Evy Lobbestael

• Publisher: Academic Press
• Year: 2017
• Print ISBN: 9780128051207
• eBook ISBN: 9780128052662
• Topic: Medicine
• Subtopic: Neurology

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.- Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress- Summarizes how patients are treated today, providing a glance at future disease management- Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists- Written and peer reviewed by outstanding scientists in their respective fields

Chapter 1

The multitude of therapeutic targets in neurodegenerative proteinopathies

Ronald Melki Paris–Saclay Institute of Neuroscience, French National Center for Scientific Research (CNRS), University of Paris–Saclay, Gif-sur-Yvette, France

Abstract

This chapter lists the different steps representing potential targets for therapeutic strategies aimed at interfering with the aggregation and propagation of proteins with prion-like properties from affected to naïve cells. The rationale for targeting each step is given. The limitations of the different possible therapeutic strategies and the time where they should be implemented are discussed.

Keywords

Alzheimer’s disease

Parkinson’s disease

Huntington’s disease

prion

proteinopathies

protein aggregates

Chapter outline

Protein Misfolding and Aggregation

Mechanism of Assembly

Prion-Like Propagation of Protein Assemblies

Propagation Routes of Pathogenic Protein Aggregates

Limiting Steps in the Propagation of Pathogenic Protein Assemblies

Therapeutic Strategies Targeting the Physiological Levels of Aggregation-Prone Proteins Involved in Neurodegeneration

Therapeutic Strategies Targeting the Misfolding and Aggregation of Proteins Involved in Neurodegeneration

Therapeutic Strategies Targeting the Accumulation of Misfolded Pathologic Protein Aggregates

Therapeutic Strategies Targeting the Cell-to-Cell Propagation of Pathogenic Protein Aggregates

Therapeutic Strategies Aimed at Restoring the Damage Pathogenic Protein Aggregates Induce

Therapeutic Strategies Targeting Misfolded Pathologic Protein Aggregate–Mediated Neuroinflammation

Limitations of the Different Therapeutic Strategies

Acknowledgments

References

Protein Misfolding and Aggregation

Within our cells, proteins are folded t...

Table of contents

• Cover
• Title page
• Table of Contents
• Copyright
• List of Contributors
• Editor Biographies
• Foreword
• Preface
• Chapter 1: The multitude of therapeutic targets in neurodegenerative proteinopathies
• Chapter 2: Synuclein misfolding as a therapeutic target
• Chapter 3: Neuroinflammation as a therapeutic target in neurodegenerative diseases
• Chapter 4A: Stem cells in neurodegeneration: mind the gap
• Chapter 4B: The potential of stem cells in tackling neurodegenerative diseases
• Chapter 5: Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy
• Chapter 6: Parkinson’s disease
• Chapter 7: Lewy body dementia
• Chapter 8: Frontotemporal dementia
• Chapter 9: From huntingtin gene to Huntington’s disease-altering strategies
• Chapter 10: Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies
• Index