Genetics and Evolution of Infectious Diseases

Michel Tibayrenc

• Publisher: Elsevier
• Year: 2010
• Topic: Biological Sciences
• eBook ISBN:
  9780123848918
• Subtopic: Oncology
• Index: Biological Sciences

Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. - Takes an integrated approach to infectious diseases - Includes contributions from leading authorities - Provides the latest developments in the field

Table of contents

• Cover Image
• Table of Contents
• Front-matter
• Copyright
• List of Contributors
• Preface
• Introduction
• 1. Virus Species
• 2. A Theory-Based Pragmatism for Discovering and Classifying Newly Divergent Bacterial Species
• 3. Population Structure of Pathogenic Bacteria
• 4. Epidemiology and Evolution of Fungal Pathogens in Plants and Animals
• 4.1. Introduction
• 4.2. Major Human and Animal Pathogenic Fungi
• 4.3. New and Emerging Mycoses
• 4.4. Plant Pathogenic Fungi
• 4.5. New and Emerging Plant Diseases
• 4.6. Modern Molecular Epidemiologic Tools for Investigating Fungal Diseases
• 4.7. Population Genetics of Pathogenic Fungi
• 4.8. Species and Speciation in Pathogenic Fungi
• 4.9. Mating and Pathogenesis
• 4.10. Genomics of Fungi: What makes a Fungus Pathogenic?
• 4.11. Conclusion
• 5. Clonal Evolution
• 6. Coevolution of Host and Pathogen
• 7. Elucidating Human Migrations by Means of their Pathogens
• 8. Phylogenetic Analysis of Pathogens
• 9. Evolutionary Responses to Infectious Disease
• 10. Infectious Disease Genomics
• 11. Proteomics and Host—Pathogen Interactions
• 12. The Evolution of Antibiotic Resistance
• 13. General Mechanisms of Antiviral Resistance
• 14. Evolution of Resistance to Insecticide in Disease Vectors
• 15. Genetics of Major Insect Vectors
• 16. Modern Morphometrics of Medically Important Insects
• 17. Multilocus Sequence Typing of Pathogens
• 18. Omics, Bioinformatics, and Infectious Disease Research
• 19. Genomics of Infectious Diseases and Private Industry
• 20. Current Progress in the Pharmacogenetics of Infectious Disease Therapy
• 21. Genetic Exchange in Trypanosomatids and Its Relevance to Epidemiology
• 22. Genomic Insights into the Past, Current and Future Evolution of Human Parasites of the Genus Plasmodium
• 23. Integrated Genetic Epidemiology of Chagas Disease
• 24. The Rise and Fall of the Mycobacterium tuberculosis Complex
• 25. The Evolution and Dynamics of Methicillin-Resistant Staphylococcus aureus
• 26. Origin and Emergence of HIV/AIDS
• 27. Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology
• 28. Ecology and Evolution of Avian Influenza Viruses