Organic Synthesis

Michael Smith, Michael B Smith

• Publisher: Academic Press
• Year: 2011
• eBook ISBN: 9780124158849
• Edition: 3
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

A reactions oriented course is a staple of most graduate organic programs, and synthesis is taught either as a part of that course or as a special topic. Ideally, the incoming student is an organic major, who has a good working knowledge of basic reactions, stereochemistry and conformational principles. In fact, however, many (often most) of the students in a first year graduate level organic course have deficiencies in their undergraduate work, are not organic majors and are not synthetically inclined.To save students much time catching up this text provides a reliable and readily available source for background material that will enable all graduate students to reach the same high level of proficiency in organic chemistry. Produced over many years with extensive feedback from students taking an organic chemistry course this book provides a reaction based approach. The first two chapters provide an introduction to functional groups; these are followed by chapters reviewing basic organic transformations (e.g. oxidation, reduction). The book then looks at carbon-carbon bond formation reactions and ways to 'disconnect' a bigger molecule into simpler building blocks.Most chapters include an extensive list of questions to test the reader's understanding. There is also a new chapter outlining full retrosynthetic analyses of complex molecules which highlights common problems made by scientists.The book is intended for graduate and postgraduate students, scientific researchers in chemistry- New publisher, new edition; extensively updated and corrected- Over 950 new references with more than 6100 references in total- Over 600 new reactions and figures replaced or updated- Over 300 new homework problems from the current literature to provide nearly 800 problems to test reader understanding of the key principles

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• About the Author
• Preface to the 3rd edition
• Preface to the 1st edition. Why I wrote this book!
• Available Separately: Introducing SpartanModel
• Dedication
• Common Abbreviations
• Chapter 1: Retrosynthesis, Stereochemistry, and Conformations
• Chapter 2: Acids, Bases and Functional Group Exchange Reactions
• Chapter 3: Oxidation
• Chapter 4: Reduction
• Chapter 5: Hydroboration
• Chapter 6: Stereocontrol and Ring Formation
• Chapter 7: Protecting Groups
• Chapter 8: Cd Disconnect Products: Nucleophilic Species that Form Carbon-Carbon Bonds
• Chapter 9: Cd Disconnect Products: Nucleophilic Species that Form Carbon-Carbon Bonds: Enolate Anions
• Chapter 10: Synthetic Strategies
• Chapter 11: Pericyclic carbon-carbon Bond Forming reactions: Multiple Bond disconnections
• Chapter 12: Ca Disconnect Products: Electrophilic Carbon-Carbon Bond-Forming Reactions
• Chapter 13: Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds via Radicals and Carbenes
• Chapter 14: Student Synthesis: The First Synthetic Problem
• Disconnection Index
• index