Genomic Biomarkers for Pharmaceutical Development
Advancing Personalized Health Care
- 208 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Genomic Biomarkers for Pharmaceutical Development
Advancing Personalized Health Care
About this book
Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development.With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development.- Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases- Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs- Authored by leading international experts from industry and academia
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Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- About the Editors
- List of Contributors
- Chapter 1. Application of Translational Science to Clinical Development
- Chapter 2. Personalized Health Care (PHC) in Cancer
- Chapter 3. Personalized Healthcare in Autoimmune Diseases
- Chapter 4. Molecular Heterogeneity, Biomarker Discovery, and Targeted Therapy in Asthma
- Chapter 5. microRNA Biomarkers as Potential Diagnostic Markers for Cancer
- Chapter 6. Toxicogenomics – A Drug Development Perspective
- Chapter 7. Translating Biomarker Discovery into Companion Diagnostics through Validation and Regulatory Consideration
- Index