Placebo and Pain

From Bench to Bedside

Luana Colloca, Magne Arve Flaten, Karin Meissner

• Publisher: Academic Press
• Year: 2013
• Print ISBN: 9780123979285
• eBook ISBN: 9780123979315
• Topic: Medicine
• Subtopic: Pharmacology

The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers' knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain:"This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School - Contains historical aspects of the placebo effect - Discusses biological and psychological mechanisms of placebo analgesic responses - Reviews implications of the placebo effect for clinical research and pain management - Includes methodological and ethical aspects of the placebo effect

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Preface
• Contributors
• Chapter 1. Historical Aspects of Placebo Analgesia
• Chapter 2. Neurochemistry of Placebo Analgesia: Opioids, Cannabinoids and Cholecystokinin
• Chapter 3. Placebo Analgesia in Rodents
• Chapter 4. Molecular Mechanisms of Placebo Responses in Humans
• Chapter 5. How does EEG Contribute to Our Understanding of the Placebo Response?: Insights from the Perspective of Bayesian Inference
• Chapter 6. Spinal Mechanisms of Placebo Analgesia and Nocebo Hyperalgesia: Descending Inhibitory and Facilitatory Influences
• Chapter 7. Spinal and Supraspinal Mechanisms of Placebo Analgesia
• Chapter 8. Positive and Negative Emotions and Placebo Analgesia
• Chapter 9. Placing Placebo in Normal Brain Function with Neuroimaging
• Chapter 10. Brain Predictors of Individual Differences in Placebo Responding
• Chapter 11. Placebo Responses, Antagonistic Responses, and Homeostasis
• Chapter 12. Placebo Analgesia, Nocebo Hyperalgesia, and Acupuncture
• Chapter 13. The Relevance of Placebo and Nocebo Mechanisms for Analgesic Treatments
• Chapter 14. How Placebo Responses are Formed: From Bench to Bedside
• Chapter 15. Methodologic Aspects of Placebo Research
• Chapter 16. Balanced Placebo Design, Active Placebos, and Other Design Features for Identifying, Minimizing and Characterizing the Placebo Response
• Chapter 17. Psychological Processes that can Bias Responses to Placebo Treatment for Pain
• Chapter 18. Against ‘Placebo.’ The Case for Changing our Language, and for the Meaning Response
• Chapter 19. Placebo Effects in Complementary and Alternative Medicine: The Self-Healing Response
• Chapter 20. Conceptualizations and Magnitudes of Placebo Analgesia Effects Across Meta-Analyses and Experimental Studies
• Chapter 21. The Contribution of Desire, Expectation, and Reduced Negative Emotions to Placebo Anti-Hyperalgesia in Irritable Bowel Syndrome
• Chapter 22. The Wound that Heals: Placebo, Pain and Surgery
• Chapter 23. What are the Best Placebo Interventions for the Treatment of Pain?
• Chapter 24. How Communication between Clinicians and Patients may Impact Pain Perception
• Chapter 25. Nocebos in Daily Clinical Practice: The Potential Side Effects of the Treatment Context and the Patient–Doctor Interaction on Pain in Clinical Populations
• Chapter 26. The Potential of the Analgesic Placebo Effect in Clinical Practice – Recommendations for Pain Management
• Chapter 27. Placebo and Nocebo: Ethical Challenges and Solutions
• Index
• Color Plates