Epigenetic Gene Expression and Regulation
eBook - ePub

Epigenetic Gene Expression and Regulation

  1. 482 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Epigenetic Gene Expression and Regulation

About this book

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. - Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science

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Yes, you can access Epigenetic Gene Expression and Regulation by Suming Huang,Michael D. Litt,C. Ann Blakey,Michael D Litt in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Genetics & Genomics. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Translational Epigenetics Series
  5. Copyright
  6. Contributors
  7. Preface
  8. Acknowledgment
  9. Chapter 1. Epigenetic gene expression—an introduction
  10. Chapter 2. Histone modifications—models and mechanisms
  11. Chapter 3. Genomic imprinting in mammals—memories of generations past
  12. Chapter 4. Polycomb and Trithorax factors in transcriptional and epigenetic regulation
  13. Chapter 5. Chromatin dynamics and genome organization in development and disease
  14. Chapter 6. ncRNA function in chromatin organization
  15. Chapter 7. Epigenetic gene regulation and stem cell function
  16. Chapter 8. Epigenetic inheritance
  17. Chapter 9. Transgenerational epigenetic regulation by environmental factors in human diseases
  18. Chapter 10. Identification of intergenic long noncoding RNA by deep sequencing
  19. Chapter 11. Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA
  20. Chapter 12. Genetically altered cancer epigenome
  21. Chapter 13. Long noncoding RNAs and carcinogenesis
  22. Chapter 14. Epigenetics of physiological and premature aging
  23. Chapter 15. Epigenetic effects of environment and diet
  24. Chapter 16. Epigenetic control of stress-induced apoptosis
  25. Chapter 17. Structure, regulation, and function of TET family proteins
  26. Chapter 18. Epigenetic drugs for cancer therapy
  27. List of acronyms and abbreviations
  28. Glossary
  29. Index