Epigenetic Biomarkers and Diagnostics
eBook - ePub

Epigenetic Biomarkers and Diagnostics

  1. 696 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Epigenetic Biomarkers and Diagnostics

About this book

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. - Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics - Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics - Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications - Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases - Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

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Information

Publisher
Academic Press
Year
2015
Print ISBN
9780128018996
eBook ISBN
9780128019214
Topic
Biological Sciences
Subtopic
Genetics & Genomics
Index
Biological Sciences

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. List of Contributors
  6. Preface
  7. Chapter 1. Epigenetic Biomarkers: New Findings, Perspectives, and Future Directions in Diagnostics
  8. Chapter 2. The Importance of Biobanks in Epigenetic Studies
  9. Chapter 3. Epigenetic Mechanisms as Key Regulators in Disease: Clinical Implications
  10. Chapter 4. The Evolution of New Technologies and Methods in Clinical Epigenetics Research
  11. Chapter 5. Biomarkers and Methodologies for Monitoring Epigenetic Drug Effects in Cancer
  12. Chapter 6. Genome-Wide Techniques for the Study of Clinical Epigenetic Biomarkers
  13. Chapter 7. Sequenom MassARRAY Technology for the Analysis of DNA Methylation: Clinical Applications
  14. Chapter 8. The Role of Methylation-Specific PCR and Associated Techniques in Clinical Diagnostics
  15. Chapter 9. Pyrosequencing and Its Application in Epigenetic Clinical Diagnostics
  16. Chapter 10. Mass Spectrometry for the Identification of Posttranslational Modifications in Histones and Its Application in Clinical Epigenetics
  17. Chapter 11. High-Throughput Analysis of Noncoding RNAs: Implications in Clinical Epigenetics
  18. Chapter 12. Circulating Noncoding RNAs as Clinical Biomarkers
  19. Chapter 13. DNA Methylation Biomarkers in Lung Cancer
  20. Chapter 14. DNA Methylation Alterations as Biomarkers for Prostate Cancer
  21. Chapter 15. DNA Methylation in Breast Cancer
  22. Chapter 16. DNA Methylation in Obesity and Associated Diseases
  23. Chapter 17. DNA Methylation Biomarkers in Asthma and Allergy
  24. Chapter 18. DNA Methylation for Prediction of Adverse Pregnancy Outcomes
  25. Chapter 19. Epigenetics in Infectious Diseases
  26. Chapter 20. DNA Methylation in Neurodegenerative Diseases
  27. Chapter 21. The Histone Code and Disease: Posttranslational Modifications as Potential Prognostic Factors for Clinical Diagnosis
  28. Chapter 22. Histone Posttranslational Modifications and Chromatin Remodelers in Prostate Cancer
  29. Chapter 23. Histone Posttranslational Modifications in Breast Cancer and Their Use in Clinical Diagnosis and Prognosis
  30. Chapter 24. Histone Variants and Posttranslational Modifications in Spermatogenesis and Infertility
  31. Chapter 25. Circulating Histones and Nucleosomes as Biomarkers in Sepsis and Septic Shock
  32. Chapter 26. Chromatin Landscape and Epigenetic Signatures in Neurological Disorders: Emerging Perspectives for Biological and Clinical Research
  33. Chapter 27. MicroRNA Deregulation in Lung Cancer and Their Use as Clinical Tools
  34. Chapter 28. Circulating Nucleic Acids as Prostate Cancer Biomarkers
  35. Chapter 29. MicroRNAs in Breast Cancer and Their Value as Biomarkers
  36. Chapter 30. MicroRNAs in Bone and Soft Tissue Sarcomas and Their Value as Biomarkers
  37. Chapter 31. miRNAs in the Pathophysiology of Diabetes and Their Value as Biomarkers
  38. Index

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Yes, you can access Epigenetic Biomarkers and Diagnostics by Jose Luis Garcia-Gimenez,José Luis García-Giménez in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Genetics & Genomics. We have over one million books available in our catalogue for you to explore.