Concepts and Models for Drug Permeability Studies

Cell and Tissue based In Vitro Culture Models

Bruno Sarmento

• Publisher: Woodhead Publishing
• Year: 2015
• Topic: Biological Sciences
• eBook ISBN:
  9780081001141
• Subtopic: Cell Biology
• Index: Biological Sciences

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. - Updated information regarding the most recent in vitro models to study the permeability of drugs - Short and concise chapters covering all the biological barriers with interest in drug permeability - A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models - Simple and clear scientific content, adaptable for young scientists and experimented researchers

Table of contents

• Cover image
• Title page
• Table of Contents
• Related titles
• Copyright
• List of contributors
• List of figures
• List of tables
• 1. Introduction
• 2. Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in early stages of drug development
• 3.1. Cell-based in vitro models for buccal permeability studies
• 3.2. Cell-based in vitro models for gastric permeability studies
• 3.3. Cell-based in vitro models for intestinal permeability studies
• 3.4. Cell-based in vitro models for nasal permeability studies
• 3.5. Cell-based in vitro models for pulmonary permeability studies
• 3.6. Cell-based in vitro models for vaginal permeability studies
• 3.7. Cell-based in vitro models for ocular permeability studies
• 3.8. Cell-based in vitro models for dermal permeability studies
• 3.9. Cell-based in vitro models for studying blood–brain barrier (BBB) permeability
• 4.1. Tissue-based in vitro and ex vivo models for buccal permeability studies
• 4.2. Tissue-based in vitro and ex vivo models for intestinal permeability studies
• 4.3. Tissue-based in vitro and ex vivo models for nasal permeability studies
• 4.4. Tissue-based in vitro and ex vivo models for pulmonary permeability studies
• 4.5. Tissue-based in vitro and ex vivo models for vaginal permeability studies
• 4.6. Tissue-based in vitro and ex vivo models for ocular permeability studies
• 4.7. Tissue-based in vitro and ex vivo models for dermal permeability studies
• 4.8. Tissue-based in vitro and ex vivo models for blood–brain barrier permeability studies
• 5. Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation: Modeling and functional extrapolation
• Index