Handbook of Basal Ganglia Structure and Function

Heinz Steiner, Kuei Y. Tseng

• Publisher: Academic Press
• Year: 2010
• Print ISBN:
  9780123747679
• eBook ISBN:
  9780080912158
• Topic: Biological Sciences
• Subtopic: Neuroscience
• Index: Biological Sciences

The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson's disease, Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiological mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction. - Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cell-molecular and cell-physiological mechanisms, and behavioral/clinical aspects of function and dysfunction - Features a truly international cast of the preeminent researchers in the field - Fully explores the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases

Table of contents

• Cover
• Halftitle
• Title
• Copyright
• Dedication
• Contributors
• Preface
• Acknowledgements
• Chapter 1 The Neuroanatomical Organization of the Basal Ganglia
• Chapter 2 The Conservative Evolution of the Vertebrate Basal Ganglia
• Chapter 3 Cell Types in the Different Nuclei of the Basal Ganglia
• Chapter 4 Neurotransmitter Receptors in the Basal Ganglia
• Chapter 5 The Striatal Skeleton: Medium Spiny Projection Neurons and their Lateral Connections
• Chapter 6 D1 and D2 Dopamine Receptor Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons
• Chapter 7 The Cholinergic Interneurons of the Striatum: Intrinsic Properties Underlie Multiple Discharge Patterns
• Chapter 8 GABAergic Interneurons of the Striatum
• Chapter 9 Endocannabinoid Signaling in the Striatum
• Chapter 10 Nitric Oxide Signaling in the Striatum
• Chapter 11 Role of Adenosine in the Basal Ganglia
• Chapter 12 Regulation of Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions
• Chapter 13 Organization of the Globus Pallidus
• Chapter 14 Projections from Pallidum to Striatum
• Chapter 15 The Subthalamic Nucleus: From In Vitro to In Vivo Mechanisms
• Chapter 16 Neurophysiology of Substantia Nigra Dopamine Neurons: Modulation by GABA
• Chapter 17 Regulation of Extracellular Dopamine: Release and Reuptake
• Chapter 18 Organization of Corticostriatal Projection Neuron Types
• Chapter 19 Gating of Cortical Input to the Striatum
• Chapter 20 Organization of Prefrontal-Striatal Connections
• Chapter 21 Gating of Limbic Input to the Ventral Striatum
• Chapter 22 Anatomical and Functional Organization of the Thalamostriatal Systems
• Chapter 23 Subcortical Connections of the Basal Ganglia
• Chapter 24 Integrative Networks Across Basal Ganglia Circuits
• Chapter 25 Synchronous Activity in Basal Ganglia Circuits
• Chapter 26 Second-Messenger Cascades
• Chapter 27 Neurotransmitter Regulation of Basal Ganglia Gene Expression
• Chapter 28 D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum: Aberrant ERK1/2 Signaling
• Chapter 29 Psychostimulant-Induced Gene Regulation in Corticostriatal Circuits
• Chapter 30 Chromatin Remodeling: Role in Neuropathologies of the Basal Ganglia
• Chapter 31 Phasic Dopamine Signaling and Basal Ganglia Function
• Chapter 32 Role of Basal Ganglia in Habit Learning and Memory: Rats, Monkeys, and Humans
• Chapter 33 Drug Addiction: the Neural and Psychological Basis of a Compulsive Incentive Habit
• Chapter 34 Parkinson’s Disease: Cross-Talk Between Environmental Factors and Gene Defects
• Chapter 35 Alterations in Corticostriatal Synaptic Function in Huntington’s and Parkinson’s Diseases
• Chapter 36 Molecular Mechanisms of L-DOPA- Induced Dyskinesia
• Chapter 37 Compensatory Mechanisms in Experimental and Human Parkinsonism: Potential for New Therapies
• Chapter 38 Pathological Synchrony of Basal Ganglia-Cortical Networks in the Systemic MPTP Primate Model of Parkinson’s Disease
• Chapter 39 Deep-Brain Stimulation for Neurologic and Psychiatric Disorders
• Index