Radicals for Life

The Various Forms of Nitric Oxide

Ernst van Faassen, Anatoly Vanin

• Publisher: Elsevier Science
• Year: 2011
• Topic: Biological Sciences
• eBook ISBN:
  9780080489599
• Subtopic: Physiology
• Index: Biological Sciences

Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. - First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes - Extensive bibliographic references, written by specialists of human physiology - Providing high scientific quality with a focus on implications for human diseases

Table of contents

• Cover image
• Title page
• Table of Contents
• Foreword
• Chapter 1: Nitric oxide radicals and their reactions
• Chapter 2: DNICs: physico-chemical properties and their observations in cells and tissues
• Chapter 3: Hypotensive, vasodilatory and anti-aggregative properties of dinitrosyl-iron complexes
• Chapter 4: DNICs and intracellular iron: nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-mediated glutathione efflux via MRP1
• Chapter 5: Low-molecular dinitrosyl iron complexes can catalyze the degradation of active centers of iron–sulfur proteins
• Chapter 6: Products of the reaction of cytosolic and mitochondrial aconitases with nitric oxide
• Chapter 7: Harnessing toxic reactions to signal stress: reactions of nitric oxide with iron–sulfur centers and the informative case of SoxR protein
• Chapter 8: Nitric oxide and dinitrosyl iron complexes: roles in plant iron sensing and metabolism
• Chapter 9: Low-molecular-weight S-nitrosothiols
• Chapter 10: S-nitrosated proteins: formation, metabolism, and function
• Chapter 11: Chemical equilibria between S-nitrosothiols and dinitrosyl iron complexes with thiol-containing ligands
• Chapter 12: Cellular non-heme iron modulates apoptosis and caspase 3 activity
• Chapter 13: Nitrite and nitrosospecies in blood and tissue: approaching the gap between bench and bedside
• Chapter 14: Nitrite as endothelial NO donor under anoxia
• Chapter 15: Nitrite as NO donor in cells and tissues
• Chapter 16: The anti-microbial and cytotoxic actions of nitrite, and the use of DNIC as a marker for these actions
• Chapter 17: Organic nitrates and nitrites as stores of NO bioactivity
• Chapter 18: Mononitrosyl-iron complexes with dithiocarbamate ligands: physico-chemical properties
• Chapter 19: Protection against allograft rejection by iron–dithiocarbamate complexes
• INDEX