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Molecular Mechanisms of Immunological Self-Recognition
Molecular Mechanisms of Immunological Self-Recognition
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Molecular Mechanisms of Immunological Self-Recognition

Frederick Alt, Henry J. Vogel
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274 pages
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English
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📖 Book - PDF

Molecular Mechanisms of Immunological Self-Recognition

Frederick Alt, Henry J. Vogel
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About This Book

Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.

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Publisher
Elsevier Science
Year
2014
ISBN
9781483215938
Topic
Medicine
Subtopic
Diseases & Allergies

Table of contents