Natural Killer Cells

Basic Science and Clinical Application

Michael T. Lotze, Angus W. Thomson

• Publisher: Academic Press
• Year: 2009
• Print ISBN: 9780123704542
• eBook ISBN: 9780080919294
• Topic: Medicine
• Subtopic: Immunology

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses.The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body.The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine.- Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners- Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

Table of contents

• Cover image
• Table of Contents
• Copyright
• Contributors
• Foreword
• Preface
• Chapter One. Developmental stages and pathways of NK cell maturation
• Chapter Two. Developmental origins of thymus-derived natural killer cells
• Chapter Three. Interferon-producing killer dendritic cells (IKDC)
• Chapter Four. Natural killer cells in cancer
• Chapter Five. NK cell immune recognition
• Chapter Six. NK cell KIR heterogeneity and evolution
• Chapter Seven. Signalling events in natural killer cells
• Chapter Eight. Human natural killer cell development
• Chapter Nine. Isolation, culture and propagation of natural killer cells
• Chapter Ten. The localization and migration of natural killer cells in health and disease
• Chapter Eleven. Receptors on NK cells
• Chapter Twelve. Development and testing of NK cell lines
• Chapter Thirteen. NK cell-derived cytokines and delivery
• Chapter Fourteen. NK cells as recipients of cytokine signals
• Chapter Fifteen. NK cells and chemokines
• Chapter Sixteen. Natural killer cytolytic activity
• Chapter Seventeen. Illuminating intranodal natural killer cell behaviour using two-photon microscopy
• Chapter Eighteen. Dendritic cells and NK cells
• Chapter Nineteen. NK and NKT cells
• Chapter Twenty. NK cell and endothelial cell interactions
• Chapter Twenty-One. Natural killer cell/epithelial interactions
• Chapter Twenty-Two. NK cell–T cell interactions
• Chapter Twenty-Three. NK cells and NKT cells in cutaneous disorders
• Chapter Twenty-Four. Natural killer cells in the respiratory tract
• Chapter Twenty-Five. Intestinal natural killer cells
• Chapter Twenty-Six. Natural killer cells in the liver
• Chapter Twenty-Seven. Natural killer cells in the spleen and lymph node
• Chapter Twenty-Eight. Nature killer cells in the central nervous system
• Chapter Twenty-Nine. NK cells in the eye
• Chapter Thirty. NK cells and reproduction
• Chapter Thirty-One. Identification of natural killer cells in tissues and their isolation
• Chapter Thirty-Two. Natural killer cell immune regulation
• Chapter Thirty-Three. Natural killer cells and transplantation
• Chapter Thirty-Four. Natural killer cells and autoimmunity
• Chapter Thirty-Five. Interaction of NK cells with bacteria
• Chapter Thirty-Six. Natural killer cells and human immunodeficiency virus
• Chapter Thirty-Seven. Cytomegalovirus infection and NK cells
• Chapter Thirty-Eight. Natural killer cells in allergy
• Chapter Thirty-Nine. Natural killer cells in wound healing
• Chapter Forty. Natural killer cells in atherosclerosis
• Chapter Forty-One. Natural killer cells in leukaemia
• Chapter Forty-Two. Natural killer cells and allogeneic haematopoietic cell transplantation
• Chapter Forty-Three. Clinical trials of NK cells for cancer
• Chapter Forty-Four. Natural killer cells and hepatitis C virus infection
• Chapter Forty-Five. Natural killer cells and the biology of parasitism
• Chapter Forty-Six. Lymphoproliferative disorders of natural killer cells
• Chapter Forty-Seven. Natural killer cell induction of tolerance
• Chapter Forty-Eight. Genetic engineering of natural killer cells
• Chapter Forty-Nine. NK cell-mediated target cell death
• Chapter Fifty. NK-cell tracking using non-invasive imaging modalities
• Subject Index