
- 845 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
About this book
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.- Edited by Nobel Laureate Louis J. Ignarro- Up-to-date therapeutic implications of nitric oxide research- Authored by world experts on nitric oxide- Detailed research of the biochemistry and synthesis of nitric oxide
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Table of contents
- Cover image
- Table of Contents
- Copyright
- Chapter 1. Determinants of Nitric Oxide Chemistry
- Chapter 2. Nitric Oxide Redox Biochemistry in Lipid Environments
- Chapter 3. Mechanisms and Biological Consequences of Peroxynitrite-Dependent Protein Oxidation and Nitration
- Chapter 4. Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes
- Chapter 5. Uncoupling of Endothelial Nitric Oxide Synthase in Cardiovascular Disease and its Pharmacological Reversal
- Chapter 6. Tetrahydrobiopterin
- Chapter 7. Regulation of the Expression of Inducible Nitric Oxide Synthase
- Chapter 8. Molecular Regulation of Inducible Nitric Oxide Synthase
- Chapter 9. Soluble Guanylate Cyclase
- Chapter 10. Untargeted Discovery of Nitric Oxide-Modified Proteins
- Chapter 11. Fatty Acid Transduction of Nitric Oxide Signaling
- Chapter 12. Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1
- Chapter 13. The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide
- Chapter 14. Nitric Oxide–Asymmetric Dimethylarginine System in Endothelial Cell Senescence
- Chapter 15. The Role of Nitric Oxide in Apoptosis and Autophagy
- Chapter 16. Nitric Oxide Formation from Inorganic Nitrate and Nitrite
- Chapter 17. Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
- Chapter 18. Nitrite Therapy for Ischemic Syndromes
- Chapter 19. Nitrite and Heme Globins
- Chapter 20. Nitric Oxide in Vascular Damage and Regeneration
- Chapter 21. Free Radicals as Atherosclerotic Risk in Relation to Nitric Oxide
- Chapter 22. The Role of Oxidative Stress in Endothelial Dysfunction and Vascular Inflammation
- Chapter 23. Nitric Oxide, Oxidative Stress, Immune Response and Critical Care
- Chapter 24. Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury
- Chapter 25. Nitric Oxide in Airway Inflammation
- Chapter 26. Novel Therapeutic Applications of Nitric Oxide in the Inhibition of Tumor Malignancy and Reversal of Resistance
- Index