The Mouse in Biomedical Research
eBook - PDF

The Mouse in Biomedical Research

Immunology

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  1. 392 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

The Mouse in Biomedical Research

Immunology

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About this book

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

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Information

Publisher
Academic Press
Year
2006
eBook ISBN
9780080469089
Edition
2
Topic
Biological Sciences
Subtopic
Zoology
Index
Biological Sciences

Table of contents

  1. Front Cover
  2. The Mouse in Biomedical Research: Immunology
  3. Copyright Page
  4. Table of Contents
  5. List of Reviewers
  6. List of Contributors
  7. Foreword
  8. Preface
  9. Overview
  10. Chapter 1. The Molecular Basis of Lymphoid Architecture in the Mouse
  11. Chapter 2. The Biology of Toll-Like Receptors in Mice
  12. Chapter 3. Genomic Organization of the Mouse Major Histocompatibility Complex
  13. Chapter 4. Some Biological Features of Dendritic Cells in the Mouse
  14. Chapter 5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes
  15. Chapter 6. Mouse Natural Killer Cells: Function and Activation
  16. Chapter 7. Cytokine-Activated JAK-STAT Signaling in the Mouse Immune System
  17. Chapter 8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
  18. Chapter 9. Mouse Models of Negative Selection
  19. Chapter 10. Peripheral Tolerance of T Cells in the Mouse
  20. Chapter 11. The Genetics of Mouse Models of Systemic Lupus
  21. Chapter 12. Inhibitory Receptors and Autoimmunity in the Mouse
  22. Chapter 13. Mouse Models of Immunodeficiency
  23. Chapter 14. Mouse Models to Study the Pathogenesis of Allergic Asthma
  24. Chapter 15. The Mouse Trap: How Well Do Mice Model Human Immunology?
  25. Index
  26. Colour Plates