Cocaine Abuse

Behavior, Pharmacology, and Clinical Applications

Stephen T. Higgins, Jonathan L. Katz

• Publisher: Academic Press
• Year: 1998
• eBook ISBN: 9780080529264
• Topic: Psychology
• Subtopic: Addiction in Psychology
• Index: Psychology

Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section of this volume. Important advances also have been made in characterizing the clinical pharmacology of cocaine, and those advances have been extended to understanding individual vulnerability to cocaine abuse, development of effective treatments, and discussions of policy. Those advances are critically reviewed in the third section of this volume. Contributors to the book were selected because of their status as internationally recognized leaders in their respective areas of scientific expertise. Moreover, each is a proponent of the importance of a rigorous, interdisciplinary scientific approach to effectively addressing the problem of cocaine abuse. As such, this volume offers a coherent, empirically-based conceptual framework for addressing cocaine abuse that has continuity from the basic research laboratory through the clinical and policy arenas. Each of the specific chapters is sufficiently detailed, in-depth and current to be valuable to informed readers with specific interests while also offering a comprehensive overview for those who might be less informed or have broader interests in cocaine abuse. This blend of critical review within each chapter with an explicitly conceptual continuity that spans all of the chapters makes this volume a unique contribution to cocaine abuse in particular and substance abuse in general. - Discusses cocaine abuse within the context of current principles of psychology, pharmacology, neuroscience, genetics and epidemiology - Chapters are all authored by scientific experts - First of its kind book on cocaine abuse to recognize behavioral/environmental determinants - Coverage is comprehensive - Informative for experts and generalists alike

Table of contents

• Front Cover
• Cocaine Abuse: Behavior, Pharmacology, and Clinical Applications
• Copyright Page
• Contents
• Contributors
• Foreword
• Preface
• Chapter 1. Basic Pharmacological Mechanisms of Cocaine
• Chapter 2. Neuroanatomical Bases of the Reinforcing Stimulus Effects of Cocaine
• Chapter 3. Behavioral Pharmacology of Cocaine and the Determinants of Abuse Liability
• Chapter 4. Behavioral-Environmental Determinants of the Reinforcing Functions of Cocaine
• Chapter 5. Tolerance and Sensitization to Cocaine: An Integrated View
• Chapter 6. Preclinical Evaluation of Pharmacotherapies for Cocaine Abuse
• Chapter 7. Prenatal Exposure to Cocaine
• Chapter 8. Cocaine Self-Administration Research: Implications for Rational Pharmacotherapy
• Chapter 9. Evaluation of Potential Pharmacotherapies: Response to Cocaine Challenge in the Human Laboratory
• Chapter 10. Controlled Laboratoy Studies on the Effects of Cocaine in Combination with Other Commonly Abused Drugs in Humans
• Chapter 11. Cocaine Effects on Brain Function
• Chapter 12. The Contribution of Genetic Factors in Cocaine and Other Durg Abuse
• Chapter 13. Vulnerability to Cocaine Abuse
• Chapter 14.Treating Cocaine Abuse: What Does Research Tell Us ?
• Chapter 15. Treatment of Cocaine Abuse in Methadone Maintenance Patients
• Chapter 16. Relapse to Cocaine Use
• Chapter 17. Cocaine Legalization: Designing the Experiments
• Index