Eukaryotic Transcription Factors
eBook - PDF

Eukaryotic Transcription Factors

  1. 391 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Eukaryotic Transcription Factors

About this book

Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. - Major families of eukaryotic transcription factors described - Mechanisms of gene activation and repression analysed - Structure-function relationships indicated - Interaction between transcription factors and chromatin structure described - Roles in inducible and cell type-specific gene expression - Roles in development, differentiation and human diseases including cancer - Methods of study in vitro and in vivo

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Information

Publisher
Academic Press
Year
2003
Edition
4
eBook ISBN
9780080531267
Topic
Medicine
Subtopic
Biochemistry in Medicine
6
EUKARYOTIC
TRANSCRIPTION
FACTORS
Figure
1.4
(a)
An
activating
molecule
(Act)
can
direct
the
acetylation
of
histones
in
the
nucleosome
(N)
thereby
resulting
in
a
change
in
chromatin
structure
from
a
tightly
packed
(wavy
line)
to
a
more
open
(solid
line)
configuration.
(b)
An
inhibitory
molecule
can
direct
the
deacetylation
of
histones
thereby
having
the
opposite
effect
on
chromatin
structure.
Figure
1.5
Demethylation
of
the
lysine
amino
acid
at
position
9
in
histone
H3
facilitates
phosphorylation
of
serine
10
and
acetylation
of
lysine
14
leading
to
a
more
open
chromatin
structure.

Table of contents

  1. Front Cover
  2. Eukaryotic Transcription Factors
  3. Copyright Page
  4. Contents
  5. List of Tables
  6. About the author
  7. Preface
  8. Preface to the third edition
  9. Preface to the second edition
  10. Preface to the first edition
  11. Acknowledgements
  12. Chapter 1. DNA Sequences, Transcription Factors and Chromatin Structure
  13. Chapter 2. Methods for Studying Transcription Factors
  14. Chapter 3. RNA Polymerases and the Basal Transcriptional Complex
  15. Chapter 4. Families of DNA Binding Transcription Factors
  16. Chapter 5. Activation of Gene Expression by Transcription Factors
  17. Chapter 6. Repression of Gene Expression by Transcription Factors
  18. Chapter 7. Regulation of Transcription Factor Synthesis
  19. Chapter 8. Regulation of Transcription Factor Activity
  20. Chapter 9. Transcription Factors and Human Disease
  21. Chapter 10. Conclusions and Future Prospects
  22. Index
  23. Color Plate Section

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Yes, you can access Eukaryotic Transcription Factors by David S. Latchman in PDF and/or ePUB format, as well as other popular books in Medicine & Biochemistry in Medicine. We have over 1.5 million books available in our catalogue for you to explore.