Extracellular Matrix and The Liver

Approach to Gene Therapy

Isao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott I. Friedman

• Publisher: Academic Press
• Year: 2003
• Print ISBN:
  9780125252515
• eBook ISBN:
  9780080531502
• Topic: Biowissenschaften
• Subtopic: Onkologie

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches. The chapters are divided into six sections as follows: - Basic Science of Extracellular Matrix - Cells Responsible for Extracellular Matrix Production - Activation Mechanism of Hepatic Cells and Signal Transduction - Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors - Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases - New Strategies for the treatment of Liver Cirrhosis - Discusses the possibility of gene therapy for liver cirrhosis - Includes information on new aspects of hepatic stellate cells - Written by top experts in basic science and clinical hepatology

Table of contents

• Front Cover
• Extracellular Matrix and the Liver
• Copyright Page
• Contents
• Contributors
• Preface
• PART I: Basic Science of Extracellular Matrix
• PART II: Cells Responsible for Extracellular Matrix Production
• PART III: Activation Mechanism of Hepatic Stellate Cells and Signal Transduction
• PART IV: Basic Science of Matrix Metalloproteinases and Tissue Inhibitor Metalloproteinases
• PART V: Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Liver Fibrosis
• PART VI: New Strategies for the Treatment of Liver Cirrhosis
• Index