Microbiology
About this book
There is a need in small group teaching for a readable module that provides a balanced treatment of the four main areas of medical microbiology-bacteriology, mycology, virology and parasistology. It need not be encyclopedic in scope nor didactic, but it should emphasise principles and concepts. Any existing gaps in this type of presentation are, of course, left for the student to fill.Some subject material has been excluded. An example is a chapter on laboratory procedures including PCR for rapid bacterial and viral diagnosis. The discussion of bacterial sexually transmitted diseases does not cover goncoccal infections. This is not a serious matter because the tutor can assign the topic to the students. Moreover, we have reluctantly omitted a separate chapter on anaerobic bacteria. The subject of nosocomial pathogens is touched upon but not in sufficient detail (e.g., control). These bacteria (e.g., S. aureus, E. coli and pseudomonas) are found in hospitals and are resistant to disinfectants and antibiotics. A new but serious problem is the emergence of resistance to antiviral agents.Without question, molecular biology owes more to the study of viruses than bacteria. The fact remains, however, that effective therapy against most viral diseases is not yet available. Perhaps one of the most dramatic examples of this situation is the fight against the AIDS virus and the search for a vaccine. The public health challenge of AIDS remains formidable in spite of the recent encouraging results obtained with protease inhibitor therapy. At the moment at least six receptors for HIV are known to be present in human cells. One of them is the CCR5 receptor in the absence of which cells fail to get infected with the virus. Drugs that can interrupt CCR5 binding sites on the virus envelope are being vigorously sought. Thus, Volume 9B gives a large place to HIV disease.The last group of chapters highlight several features of microbiology which are also of clinical importance and heuristic value. The chapter on fever of unknown origin provides fertile soil for problem based learning.
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Table of contents
- Cover
- Contents
- List of Contributors
- Preface
- Chapter 1. Ultrastructure of Bacteria
- Chapter 2. The Bacterial Outer Membrane and Surface Permeability
- Chapter 3. Bacterial Metabolism
- Chapter 4. Bacterial Genetics
- Chapter 5. Regulation of Cytoplasmic pH in Bacteria
- Chapter 6. Vertebrate Hormones in Bacteria and Microbial Eukaryotes
- Chapter 7. Principles of Bacterial Pathogenesis
- Chapter 8. Selected Bacteria of Medical Importance
- Chapter 9. Tuberculosis
- Chapter 10. Mycobacterium Avium-Intracellulare (MAI)
- Chapter 11. Hansen Disease
- Chapter 12. Antimicrobial Therapy
- Chapter 13. Mechanisms of Resistance to Antibacterial Agents
- Chapter 14. Lyme Disease
- Chapter 15. Syphilis
- Chapter 16. Brucellosis
- Chapter 17. Fungal Diseases
- Chapter 18. The Rickettsiae
- Chapter 19. Chlamydia
- Chapter 20. Viral Membranes
- Chapter 21. Principles of Retrovirus Assembly
- Chapter 22. Virus-Induced Alterations in Cells
- Chapter 23. Retroviral Vectors
- Chapter 24. Herpesviruses
- Chapter 25. Respiratory Tract Viruses
- Chapter 26. The Interferons
- Chapter 27. Genetics and Molecular Biology of AIDS Virus
- Chapter 28. AIDS Epidemiology in the United States
- Chapter 29. The Global Epidemiology of AIDS
- Chapter 30. Diagnostic Virology
- Chapter 31. Antiviral Chemotherapy
- Chapter 32. From Jenner to Genes„The Next Generation of Virus Vaccines
- Chapter 33. Principles of Parasitology and Parasitic Disorders
- Chapter 34. The Molecular Epidemiology of Parasites
- Chapter 35. Chemotherapeutic Agents Used in Tropical Medicine
- Chapter 36. Toxin-Induced Diseases
- Chapter 37. The Pathogenesis of Sepsis
- Chapter 38. Bacterial Meningitis
- Chapter 39. Fever of Unknown Origin in the General Population and in HIV-infected Persons
- Index
