Serotonin Receptors and their Ligands
eBook - PDF

Serotonin Receptors and their Ligands

  1. 379 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Serotonin Receptors and their Ligands

About this book

An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters.The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account.The (potential) therapeutic applications of ligands of the different subtypes are described.Altogether an excellent addition to the Pharmacochemical Library series.

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Information

Publisher
Elsevier Science
Year
1997
Print ISBN
9780444820419
eBook ISBN
9780080541112
Topic
Scienze fisiche
Subtopic
Farmacologia

Table of contents

  1. Front Cover
  2. SEROTONIN RECEPTORS AND THEIR LIGANDS
  3. Copyright Page
  4. CONTENTS
  5. Preface
  6. CHAPTER 1. SEROTONIN RECEPTOR SUBTYPES (Chapter 1)
  7. CHAPTER 2. 5-HT1A RECEPTORS (Chapter 2)
  8. CHAPTER 3. 5-HT1B RECEPTORS (Chapter 3)
  9. CHAPTER 4. 5-HT1D RECEPTORS (Chapter 4)
  10. CHAPTER 5. 5-HT1E, 5-HT1F RECEPTORS (Chapter 5)
  11. CHAPTER 6. 5-HT2A, 5-HT2B and 5-HT2C RECEPTORS (Chapter 6)
  12. CHAPTER 7. 5-HT3 RECEPTORS (Chapter 7)
  13. CHAPTER 8. 5-HT4 RECEPTORS (Chapter 8)
  14. CHAPTER 9. 5-HT5, 5-HT6 and 5-HT7 RECEPTORS (Chapter 9)
  15. CHAPTER 10. 5-HT TRANSPORTER (Chapter 10)
  16. Index

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Yes, you can access Serotonin Receptors and their Ligands by B. Olivier,I. van Wijngaarden,W. Soudijn in PDF and/or ePUB format, as well as other popular books in Scienze fisiche & Farmacologia. We have over 1.5 million books available in our catalogue for you to explore.