Viral Vectors
eBook - PDF

Viral Vectors

Gene Therapy and Neuroscience Applications

  1. 486 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Viral Vectors

Gene Therapy and Neuroscience Applications

About this book

Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells.Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers.This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.

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Yes, you can access Viral Vectors by Michael G. Kaplitt,Arthur D. Loewy in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Front Cover
  2. VIRAL VECTORS: Gene Therapy and Neuroscience Applications
  3. Copyright Page
  4. Contents
  5. Contributors
  6. Preface
  7. Acknowledgments
  8. Chapter 1. Herpes Simplex Virus as a Gene-Delivery Vector for the Central Nervous System
  9. Chapter 2. Biology of Herpes Simplex Virus (HSV) Defective Viruses and Development of the Amplicon System
  10. Chapter 3. Group C Adenoviruses as Vectors for Gene Therapy
  11. Chapter 4. Genetics and Biology of Adeno-Associated Virus
  12. Chapter 5. Genetics and Biology of Retroviral Vectors
  13. Chapter 6. HSV Vectors in the Mammalian Brain: Molecular Analysis of Neuronal Physiology, Generation of Genetic Models, and Gene Therapy of Neurological Disorders
  14. Chapter 7. The Use of Defective Herpes Simplex Virus Amplicon Vectors to Modify Neural Cells and the Nervous System
  15. Chapter 8. Viral Vector-Mediated Gene Transfer in the Nervous System: Application to the Reconstruction of Neural Circuits in the Injured Mammalian Brain
  16. Chapter 9. The Use of Herpes Simplex Virus Vectors for Protection from Necrotic Neuron Death
  17. Chapter 10. In Viva Promoter Analysis in the Adult Central Nervous System Using Viral Vectors
  18. Chapter 11. Adenoviral-Mediated Gene Transfer: Potential Therapeutic Applications
  19. Chapter 12. Transfer and Expression of Potentially Therapeutic Genes into the Mammalian Central Nervous System in Viva Using Adeno-Associated Viral Vectors
  20. Chapter 13. Genetic Modification of Cells with Retrovirus Vectors for Grafting into the Central Nervous System
  21. Chapter 14. Virus Vector-Mediated Transfer of Drug-Sensitivity Genes for Experimental Brain Tumor Therapy
  22. Chapter 15. Brain Tumor Therapy Using Genetically Engineered Replication-Competent Virus
  23. Chapter 16. Transfer and Expression of Antioncogenes and Paraneoplastic Genes in Normal and Neoplastic Cells in Vitro and in Viva
  24. Chapter 17. Transneuronal Tracing with Alpha-herpesviruses: A Review of the Methodology
  25. Chapter 18. Pseudorabies Virus Replication and Assembly in the Rodent Central Nervous System
  26. Chapter 19. Pseudorabies Virus: A Transneuronal Tracer for Neuroanatomical Studies
  27. Chapter 20. Molecular Properties of Alphaherpesviruses Used in Transneuronal Pathway Tracing
  28. Chapter 21. Molecular Analysis of Rabies and Pseudorabies Neurotropism
  29. Chapter 22. The Use of Retroviral Vectors in the Study of Cell Lineage and Migration during the Development of the Mammalian Central Nervous System
  30. Chapter 23. Retroviral Vectors for the Study of Neuroembryology: Immortalization of Neural Cells
  31. Index
  32. Color Plate Section