Commentary and Annotation Biographical Sketch
Ludwik Fleck was an unusual man, a humanist with an encyclopedic knowledge. He had a very keen sense of humor and was erudite in many fields. In his person were united the excellence of a distinguished microbiologist and the depth and insight of a great philosopher.
Fleck was born in Lvov, Poland, 11 July 1896, to Maurycy Fleck and Sabina (neĂ© Herschdörfer). He attended grammar school and high school in Lvov, where the German language still dominated from the period when Lvov, as Lemberg, had belonged to the Austrian Empire. In 1922, at the age of twenty-six, Fleck received his medical degree from Lvov University. From 1920 to 1923 he was assistant to Dr. Rudolf Weigl, well known for his research on typhus, both at the Typhus Investigation Laboratory of Lvov University and at the State Hospital for Infectious Diseases. He later specialized in bacteriology in Vienna. From 1925 to 1927 Fleck was head of the bacteriological and chemical laboratories of the State Hospital in Lvov. He spent the year 1927 in Vienna (during the heyday of the Vienna Circle), working in the State Serotherapeutic Institute under the direction of Dr. Kraus. From 1928 he was head of the bacteriological laboratory of the Social Sick Fund in Lvov until his dismissal in 1935âan anti-Jewish measure.
By 1935 Fleck had already published extensively on various aspects of general serology, hematology, experimental medicine, immunology, and bacteriology. Among the specific topics of his research were the serology of typhus fever, syphilis, and a variety of pathogenic microorganisms. Before World War II, Fleck carried out extensive research on epidemic typhus fever. He developed an original method to obtain a vaccine and a diagnostic skin test, which he designated the âexanthin reaction.â This was internationally confirmed and is mentioned in textbooks. Besides his specialized scientific research on cytoserology and infectious diseases (including the concept of infection), Fleck published seven papers on methodology of science, some articles on the methodology of scientific observation, on principles of medical knowledge, on the history of discoveries, etc. He also developed an original theory about thought style and thought collectives which he formulated in the monograph translated above. Completed in 1934, the work was published in 1935 in Switzerland (because political conditions in 1935 did not permit a Jew to publish in Germany) and was widely discussed in Poland, Germany, France, Italy, and Switzerland.
Between 1935 and 1939 Fleck worked in private practice at Lvov in his private microbiological laboratory, where he could also pursue his research. It was here that he continued his investigations into the variability of streptococci and the etiology of pemphigus vulgaris. He examined the role of normal sera on the course of serologic reactions, found a new method to strengthen the sensitivity of the Wassermann reaction, and discovered an original method for distinguishing true serological reactions from pseudoreactions. In December 1939, after the Russian takeover of Lvov (it is today just within the Ukrainian Republicâs borders), Fleck was made director of the City Microbiological Laboratory. At the same time he was appointed to the teaching staff in the microbiology department of the State Medical School in Lvov. Until 1941 he also served as head of the microbiology department of the State Bacteriological Institute in Lvov as well as consultant in immunology and serology at the State Institute of Mother and Child Welfare in that city.
During the German occupation of Lvov from 1941, Fleck was director of the bacteriological laboratory of the Jewish Hospital there until the following December. Concerned with the severe typhus epidemic which arose under the ghetto conditions, he succeeded with very primitive means to develop a rapid diagnostic test for typhus, which permitted early detection and isolation. The excretion of a specific ...