Molecular Basis of Biological Degradative processes

Richard Berlin

• Publisher: Academic Press
• Year: 2012
• Print ISBN:
  9780120921508
• eBook ISBN:
  9780323155045
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Molecular Basis of Biological Degradative Processes contains the proceedings of the 1977 symposium held at the University of Connecticut Health Science Center. The papers focus on the molecular mechanisms underlying the biological degradation, including the relationship between the lysosome and tissue remodeling and the role of this organelle in processing intra- and extracellular material. The book also explores the specific application of the lysosome concept to the description of deficiency diseases of lipid catabolism. Organized into 12 chapters, this book begins with an overview of the mechanisms underlying cell death and its control, along with possible experimental models for its study, nutrient deficiencies during prenatal development, and congenital diseases resulting from zinc, magnesium, and manganese deficiencies. It explains the clinical lysosome deficiencies, the early phase of blood coagulation, cascade events in the activation and function of mast cells, activation of plasminogen and its involvement in the production of localized extracellular proteolysis, and proteolytic events in viral replication. Chapters on human neutrophil elastase and the protease-pathogenesis model of pulmonary emphysema; dissolution mechanism of apatite crystals during dental caries and bone resorption; and degradative processes of bone follow. This book is a valuable resource for biologists, physiologists, and those involved in basic and applied research in ""catabolic"" processes.

Table of contents

• Front Cover
• Molecular Basis of Biological Degradative Processes
• Copyright Page
• Table of Contents
• CONTRIBUTORS
• PREFACE
• CHAPTER 1. DEVELOPING ORGANISMS AS MODEL SYSTEMS FOR THE STUDY OF DEGRADATIVE PROCESSES
• CHAPTER 2. AN INTEGRATED VIEW OF LYSOSOME FUNCTION
• CHAPTER 3. ELUCIDATION OF CLINICAL LYSOSOME DEFICIENCIES
• CHAPTER 4. COMPLEMENT: MOLECULAR MECHANISMS, REGULATION AND BIOLOGIC FUNCTION
• CHAPTER 5. THE EARLY PHASE OF BLOOD COAGULATION
• CHAPTER 6. CASCADE EVENTS IN MAST CELL ACTIVATION AND FUNCTION
• CHAPTER 7. ACTIVATION OF PLASMINOGEN: A GENERAL MECHANISM FOR PRODUCING LOCALIZED EXTRACELLULAR PROTEOLYSIS
• CHAPTER 8. PROTEOLYTIC EVENTS IN VIRAL REPLICATION
• CHAPTER 9. HUMAN NEUTROPHIL ELASTASE AND THE PROTEASE-PATHOGENESIS MODEL OF PULMONARY EMPHYSEMA
• CHAPTER 10. DENTAL CARIES
• CHAPTER 11. DISSOLUTION MECHANISMS OF THE APATITE CRYSTALS DURING DENTAL CARIES AND BONE RESORPTION
• CHAPTER 12. DEGRADATIVE PROCESSES OF BONE