- 321 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
About this book
The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.
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Table of contents
- Front Cover
- The Mouse in Biomedical Research: History, Genetics, and Wild Mice
- Copyright Page
- Table of Contents
- Preface
- List of Reviewers for Chapters in This Volume
- Chapter 1. The Laboratory Mouse—A Historical Perspective
- Chapter 2. Taxonomy
- Chapter 3. Nomenclature
- Chapter 4. Wild Mice
- Chapter 5. Breeding Systems
- Chapter 6. Gene Mapping
- Chapter 7. The Histocompatibility-2 (H-2) Complex
- Chapter 8. Genetic Monitoring
- Chapter 9. Inbred and Segregating Inbred Strains*
- Chapter 10. Congenic Strains
- Chapter 11. Recombinant Inbred Strains and Bilineal Congenic Strains*
- Chapter 12. Cytogenetics
- Chapter 13. Radiation Genetics
- Chapter 14. Selected Aspects of Pharmacogenetics
- Addendum: The Histoconipatibility-2 (H-2) Complex
- Index
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Yes, you can access The Mouse in Biomedical Research by Henry Foster in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Botany. We have over 1.5 million books available in our catalogue for you to explore.