Chemistry and Biology of Nucleosides and Nucleotides
eBook - PDF

Chemistry and Biology of Nucleosides and Nucleotides

  1. 490 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Chemistry and Biology of Nucleosides and Nucleotides

About this book

Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

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Yes, you can access Chemistry and Biology of Nucleosides and Nucleotides by Robert Harmon in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Front Cover
  2. Chemistry and Biology of Nucleosides and Nucleotides
  3. Copyright page
  4. Dedication
  5. Table of Contents
  6. List of Contributors
  7. Preface
  8. CHAPTER 1. TOTAL SYNTHESIS OF A BACTERIAL GENE II: THE TOTAL DNA INCLUDING THE PROMOTER AND ITS TRANSCRIPTION*
  9. CHAPTER 2. TOTAL SYNTHESIS OF A BACTERIAL GENE I: CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES AND USE OF HIGH-PRESSURE LIQUID CHROMATOGRAPHY1
  10. CHAPTER 3. THE USE OF MICROPARTICULATE REVERSED-PHASE PACKING IN HIGH-PRESSURE LIQUID CHROMATOGRAPHY OF NUCLEOSIDES*
  11. CHAPTER 4. CHEMICAL AND ENZYMATIC METHODS IN THE SYNTHESIS OF MODIFIED POLYNUCLEOTIDES*
  12. CHAPTER 5. SIMPLE MODELS OF NUCLEIC ACID INTERACTIONS
  13. CHAPTER 6. SYNTHESIS OF NUCLEOTIDES WHICH INACTIVATE ENZYMES UTILIZING ADENINE NUCLEOTIDES
  14. CHAPTER 7. SYNTHESIS, ANTIVIRAL ACTIVITY, AND MECHANISM OF ACTION OF A NOVEL SERIES OF PYRIMIDINE NUCLEOSIDE ANALOGS*
  15. CHAPTER 8. THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF C-NUCLEOSIDES RELATED TO PSEUDOURIDINE*
  16. CHAPTER 9. THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF CERTAIN 4-SUBSTITUTED AND 3,4-DISUBSTITUTED PYRAZOLO(3,4-d)PYRIMIDINE NUCLEOSIDES*
  17. CHAPTER 10. THE CHEMISTRY AND BIOLOGY OF SOME NEW NUCLEOSIDE ANALOGS ACTIVE AGAINST TUMOR CELLS
  18. CHAPTER 11. POTEfJTIATION OF THE CHEMOTHERAPEUTIC ACTION OF ANTINEOPLASTIC AGENTS BY NUCLEOSIDES
  19. CHAPTER 12. COFORMYCIN AND DEOXYCOFORMYCIN: TIGHT-BINDING INHIBITORS OF ADENOXINE DEAMINASE
  20. CHAPTER 13. SYNTHESIS AND CHEMISTRY OF A NEW ANTIVIRALANTIBIOTIC NUCLEOSIDE IN THE ANHYDRO FORM: APPLICATION OF A NOVEL 1,3-ELECTROPHILIC (C-N-C) ANNULATION REAGENT
  21. CHAPTER 14. SYNTHESIS OF 1-(2-DEOXY-$-D-Ribofuranosyl)-5,6- DIHYDRO-5-METHYL-S-TRIAZIN-2,4(1H,3H)Dione
  22. CHAPTER 15. AN APPROACH TO THE SYNTHESIS OF 1, 9-DIRIBOSYL PURINE
  23. CHAPTER 16. AN INITIAL STUDY ON THE SELECTIVITY AND STEREOSPECIFICITY OF THE RIBOSYLATION REACTION
  24. CHAPTER 17. ON THE MECHANISM OF NUCLEOSIDE SYNTHESIS
  25. CHAPTER 18. SYNTHESIS AND CHEMISTRY OF CERTAIN AZOLE NUCLEOSIDES
  26. CHAPTER 19. THE SYNTHESIS OF HETEROCYCLIC ANALOGS OF PURINE NUCLEOSIDES AND NUCLEOTIDES CONTAINING A BRIDGEHEAD NITROGEN ATOM
  27. CHAPTER 20. DETERMINATION OF THE SITE OF GLYCOSYLATION IN VARIOUS NUCLEOSIDES BY CARBON-13 NMR SPECTROSCOPY
  28. CHAPTER 21. A "GEOMETRY-ONLY" H NMR METHOD FOR DETERMINATION OF THE ANOMERIC CONFIGURATION OF RIBOFURANOSYL COMPOUNDS*
  29. CHAPTER 22. INVESTIGATION OF NUCLEOSIDE ALKYLPHOSPHONATES
  30. CHAPTER 23. THE TER T-BUTYLDIMETHYLSILYL GROUP AS A PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS
  31. CHAPTER 24. ADVANCES IN THE SYNTHESIS OF C-GLYCOSYL NUCLEOSIDES
  32. CHAPTER 25. SYNTHESIS OF C-GLYCOSYL THIAZOLES
  33. CHAPTER 26. A NEW METHOD FOR THE SYNTHESIS OF 2*-DEOXY-2'- SUBSTITUTED PURINE NUCLEOSIDES. SYNTHESIS OF THE ANTIBIOTIC 2■-DEOXY-2'-AMINOGUANOSINE
  34. CHAPTER 27. SYNTHESIS AND REACTION OF NUCLEOSIDES CONTAINING SULFUR FUNCTIONS IN THE SUGAR PORTION*
  35. CHAPTER 28. NEW C-NUCLEOSIDE ISOSTERES OF SOME NUCLEOSIDE ANTIBIOTICS*
  36. Index