Cell Cycle Regulation

James R. Jr. Jeter

• Publisher: Academic Press
• Year: 2012
• Print ISBN: 9780123846501
• eBook ISBN: 9780323158169
• Topic: Biological Sciences
• Subtopic: Cell Biology
• Index: Biological Sciences

Cell Cycle Regulation describes the interaction of the nuclear genome, the cytoplasmic pools, the organelles, the cell surface, and the extracellular environment that govern the cell cycle regulation. Comprised of 12 chapters, this book includes cell cycle regulation around nuclear chromatin modulation and some aspects of chromatin modification and its effects on gene expression. The opening chapters describe the macromolecular structure of chromatin subunits and the types and kinds of postsynthetic modifications occurring on histones, such as acetylation, methylation, and phosphorylation. The subsequent chapter deals extensively on histone phosphorylation, especially histone H1, H1M, H2A, and H3, during the cell cycle. Another chapter describes a selective histone leakage from nuclei during isolation accounting for the role of histone acetylation and phosphorylation in gene expression. This book goes on examining the assembly of microtubules and structural analysis on the regulatory role of calcium into a pattern for mitosis regulation. Other chapters discuss the methods used to measure intracellular pH changes as a function of the cell cycle of Physarum and the quantitative and qualitative changes taking place during the various phases of the cell cycle. The use of mammalian cell fusion to study cell cycle regulation and the protein synthesis regulation during the cell cycle in Chlamydomonas reinhardi are then discussed. The final chapters focus on the regulation of expression of an inducible structural gene during the cell cycle of the green alga Chlorella. The chapters provide evidence for a model of positive and negative oscillatory control of inducible gene expression. An analysis of the expression of cytoplasmic genes as a function of the cell cycle using pedigrees of a large number of individual yeast cells is also included. This book will appeal to a wide variety of life scientists and to molecular, cellular, and developmental biologists.

Table of contents

• Front Cover
• Cell Cycle Regulation
• Copyright Page
• Table of Contents
• List of Contributors
• Preface
• Chapter 1. Cell Cycle Regulation: Editors' Introduction to the Presentations
• Chapter 2. Some Aspects of Chromatin Structure and Cell-Cycle-Related Postsynthetic Modifications
• Chapter 3. Histone Phosphorylation and Chromatin Structure in Synchronized Mammalian Cells
• Chapter 4. The Binding of Histones in Mammalian Chromatin: Cell-Cycle-Induced and SV40-lnduced Changes
• Chapter 5. Triggers, Trigger Waves, and Mitosis: A New Model
• Chapter 6. Intracellular pH and the Mitotic Cycle in Physarum and Mammalian Cells
• Chapter 7. Cell Fusion and Regulation of DNA Synthesis
• Chapter 8. Regulation of Gene Expression in the Cell Cycle of Physarum
• Chapter 9. Regulation of Protein Synthesis during the Cell Cycle in Chlamydomonas reinhardi
• Chapter 10. Regulation of Glutamate Dehydrogenase Induction and Turnover during the Cell Cycle of the Eukaryote Chlorella
• Chapter 11. The Effect of Different Cell Cycles in Yeast on Expression of the Cytoplasmic Petite Mutation
• Chapter 12. Epidermal Proliferation in Lower Vertebrates
• Author Index
• Subject Index