Strategies and Tactics In Organic Synthesis

Thomas Lindberg

• Publisher: Academic Press
• Year: 2012
• Print ISBN:
  9780124502802
• eBook ISBN:
  9780323152938
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

Strategies and Tactics in Organic Synthesis presents the chronological development of ideas and experimentation in organic synthesis. This book is organized into 13 chapters that explore the synthetic pathways of various organic compounds. The first four chapters describe the variations in the synthesis of superphane, gibberellic acid, prostaglandin, and alkaloids. The following chapters cover the organic synthesis and biosynthesis of tylonolide, endiandric acids A-G, dodecahedrane, fomannosin, and illudol. A chapter focuses on the evolution of the total synthesis of jatrophone, an architecturally interesting macrocyclic diterpene extracted from Jatropha gossypiifolia. Another chapter discusses the heuristic principle for the stereorationale design of alkaloid syntheses. The remaining chapters discuss the approach to the total synthesis of steroids, streptonigrin, methynolide, and Prelog-Djerassi lactonic acid. Organic chemists, teachers, and students will find this book of great value.

Table of contents

• Front Cover
• Strategies and Tactics in Organic Synthesis
• Copyright Page
• Table of Contents
• CONTRIBUTORS
• PREFACE
• CHAPTER 1. THEME AND VARIATIONS: A SYNTHESIS OF SUPERPHANE
• CHAPTER 2. THE TOTAL SYNTHESIS OF GIBBERELLIC ACID
• CHAPTER 3. A PROSTAGLANDIN SYNTHESIS
• CHAPTER 4. SYNTHESIS OF INDOLE ALKALOIDS
• CHAPTER 5. SYNTHESIS OF TYLONOLIDE, THE AGLYCONE OF TYLOSIN
• CHAPTER 6. PERICYCLIC REACTIONS IN ORGANIC SYNTHESIS AND BIOSYNTHESIS: SYNTHETIC ADVENTURES WITH ENDIANDRIC ACIDS A – G
• CHAPTER 7. PLATO'S SOLID IN A RETORT: THE DODECAHEDRANE STORY
• CHAPTER 8. THE SYNTHESIS OF FOMANNOSIN AND ILLUDOL
• CHAPTER 9. EVOLUTION OF A SYNTHETIC STRATEGY: TOTAL SYNTHESIS OF JATROPHONE
• CHAPTER 10. ON THE STEREOCHEMISTRY OF NUCLEOPHILIC ADDITIONS TO TETRAHYDROPYRIDINIUM SALTS: A POWERFUL HEURISTIC PRINCIPLE FOR THE STEREORATIONALE DESIGN OF ALKALOID SYNTHESES
• CHAPTER 11. A NONBIOMIMETIC APPROACH TO THE TOTAL SYNTHESIS OF STEROIDS: THE TRANSITION METAL-CATALYZED CYCLIZATION OF ALKENES AND ALKYNES
• CHAPTER 12. EVOLUTION OF A STRATEGY FOR TOTAL SYNTHESIS OF STREPTONIGRIN
• CHAPTER 13. METHYNOLIDE AND THE PRELOG-DJERASSI LACTONIC ACID: AN EXERCISE IN STEREOCONTROLLED SYNTHESIS
• INDEX