Ether Lipids

Biochemical and Biomedical Aspects

H.K. Mangold

• Publisher: Academic Press
• Year: 2012
• Print ISBN:
  9780124687806
• eBook ISBN:
  9780323149723
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Ether Lipids: Biochemical and Biomedical Aspects is a 21-chapter text that explores the procedures for the analysis, synthesis, and biomedical application of ether lipids. This book surveys first the chromatographic analysis of ether lipids and their characterization by mass spectrometry. The following chapter describes the chemical synthesis of lipids containing alkyl or 1-alkenyl chains. Three chapters are devoted to the biosynthesis of ether lipids, and four others cover unusual ether lipids. Significant chapters focus on biologically active ether lipids, including the naturally occurring platelet-activating factor and synthetic alkyl analogs of lysophosphatidylcholines, which exhibit cancerostatic properties. This text further discusses the application of these and related substances in biomedical research as well as in clinical diagnosis and therapy. The remaining chapters highlight the use of ether lipids in studies aimed at elucidating the structure of membranes and their functions. Organic chemists, biochemists, and researchers in the biomedical field will find this book invaluable.

Table of contents

• Front Cover
• Ether Lipids: Biochemical and Biomedical Aspects
• Copyright Page
• Table of Contents
• Contributors
• Preface
• Terminology and Abbreviations
• Chapter 1. Chromatographie Analysis, Isolation, and Characterization of Ether Lipids
• Chapter 2. Mass Spectrometry of Ether Lipids
• Chapter 3. Chemical Synthesis of Ether Lipids
• Chapter 4. Biosynthesis of O-Alkylglycerol Ether Lipids
• Chapter 5. Biosynthesis of 1-O-(1'Alkenyl)glycerolipids (Plasmalogens)
• Chapter 6. Substrate Specificity of Enzymes Catalyzing the Biosynthesis of Ether Lipids
• Chapter 7. Ether Glycolipids
• Chapter 8. Dialkyidiglycerol Tetraethers
• Chapter 9. Ether Lipids Containing Steryl Moieties
• Chapter 10. Divinyl Ether Fatty Acids
• Chapter 11. Autoxidation of Ether Lipids
• Chapter 12. Ether Lipids as Substrates for Lipolytic Enzymes
• Chapter 13. Ether Lipids in the Diet of Humans and Animals
• Chapter 14. Ether Lipids in Clinical Diagnosis and Medical Research
• Chapter 15. Therapeutic Effects of Ether Lipids
• Chapter 16. Synthetic Alkyl Analogs of Lysophosphatidylcholme: Membrane Activity, Metabolic Stability, and Effects on Immune Response and Tumor Growth
• Chapter 17. Ether Lipids in Biological and Model Membranes
• Chapter 18. Platelet-Activating Factor: An Ether Lipid with Biological Activity
• Chapter 19. Procedures for the Analysis of Ether Lipids
• Chapter 20. Procedures for the Synthesis of Ether Lipids
• Chapter 21. Procedures for Biomédical Investigations
• Index