Cellular Responses to Molecular Modulators

Lee Mozes

• Publisher: Academic Press
• Year: 2012
• Print ISBN: 9780125093804
• eBook ISBN: 9780323145367
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Miami Winter Symposia, Volume 18: Cellular Responses to Molecular Modulators is a collection of papers presented at the 13th Miami Winter Symposium held in Miami Beach in 1981 through the joint effort of the University of Miami School of Medicine and the Papanicolaou Cancer Research Institute. Separating 27 manuscripts into chapters, this book begins with a discussion on protein structure and function. This topic is followed by considerable chapters devoted to a whole series of molecules that precisely and specifically modulate a particular behavior and that can be studied in detail in isolated cells in culture. These chapters also look into the research studies on mitogen receptor cytobiochemistry, including special insertion properties and internal migratory fate after binding to effectors. Other chapters discuss the primary gene product containing the thymosin ?1 sequence; the purification and production of interferons from cell cultures; the biochemical mechanisms by which interferons modulate cell behavior; and the ability of interferons to regulate natural killer lytic activity at the single cell or population level. The concluding chapters explore the distinct interferon classes by their antigenic, biological, and chemical properties. This book will be of great benefit to cell biologists and researchers.

Table of contents

• Front Cover
• Cellular Responses to Molecular Modulators
• Copyright Page
• Table of Contents
• SPEAKERS AND DISCUSSANTS
• PREFACE
• CHAPTER 1. FROM CARBODIIMIDE TO GENE SYNTHESIS
• CHAPTER 2. DENSITY, ANCHORAGE, AND MOLECULAR MODULATORS. A REAPPRAISAL
• CHAPTER 3. ON THE REGULATION OF EUKARYOTIC CELL GROWTH: AN APPROACH TO THE BEHAVIOR OF NORMAL AND TRANSFORMED CELLS
• CHAPTER 4. Molecular Analysis of the Mitogenic Response to Platelet-Derived Growth Factor
• CHAPTER 5. POLYOMA HOST RANGE MUTANTS THAT REPLICATE IN EMBRYONAL CARCINOMA CELLS
• CHAPTER 6. MECHANISM OF MITOGENIC MESSAGE TRANSMISSION IN HORMONE ACTION
• CHAPTER 7. THE EXTRACELLULAR MATRIX AND THE CONTROL OF CELL PROLIFERATION AND DIFFERENTIATION
• CHAPTER 8. THE ROLE OF THE RECEPTOSOME IN RECEPTOR–MEDIATED ENDOCYTOSIS
• CHAPTER 9. Na INFLUX AS A MITOGENIC SIGNAL FOR CULTURED FIBROBLASTIC CELLS
• CHAPTER 10. GROWTH FACTORS FROM THE PLATELET, THE MONOCYTE /MACROPHAGE AND THE ENDOTHELIAL CELL: THEIR POTENTIAL ROLE IN BIOLOGY
• CHAPTER 11. TRANSFORMING GROWTH FACTORS PRODUCED BY HUMAN TUMOR CELLS: INTERACTION WITH EPIDERMAL GROWTH FACTOR (EGF) MEMBRANE RECEPTORS
• CHAPTER 12. MECHANISM OF ACTION OF NERVE GROWTH FACTOR
• CHAPTER 13. COLONY STIMULATING FACTOR AND THE GRANULOCYTE MACROPHAGE PROGENITOR CELL 1
• CHAPTER 14. RECENT DEVELOPMENTS IN THE CHEMISTRY, BIOLOGY AND CLINICAL APPLICATIONS OF THYMOSIN
• CHAPTER 15. PRODUCTION OF BIOLOGICALLY ACTIVE N α -DESACETYL THYMOSIN α i IN ESCHERICHIA COLI THROUGH EXPRESSION OF A CHEMICALLY SYNTHESIZED GENE
• CHAPTER 16. PURIFICATION AND CHARACTERIZATION OF LYMPHOKINE FRACTIONS ASSOCIATED WITH TUMOR IMMUNOTHERAPEUTIC ACTIVITY 1
• CHAPTER 17. RECEPTOR AND NON–RECEPTOR ASSOCIATED, LYMPHOCYTE-DERIVED CELL–LYTIC MOLECULES 1
• CHAPTER 18. BIOSYNTHESIS OF THYMIC PEPTIDES
• CHAPTER 19. HOW MANY INTERFERONS ARE THERE?
• CHAPTER 20. THE 2-5A SYSTEM IN INTERFERON-TREATED AND CONTROL CELLS
• CHAPTER 21. INTERFERON–INDUCED ENZYMES: SYNTHESIS AND FUNCTION IN THE CELL–REGULATORY ACTION OF INTERFERONS
• CHAPTER 22. MECHANISMS OF INTERFERON ACTION ON CELL GROWTH AND ON MURINE LEUKEMIA, VESICULAR STOMATITIS, AND ENCEPHALOMYOCARDITIS VIRUSES
• CHAPTER 23. REGULATION OF CYTOTOXIC CELLS BY INTERFERON
• CHAPTER 24. INHIBITION OF CELL PROLIFERATION AND LOCOMOTION BY INTERFERON: MEMBRANE AND CYTOSKELETAL CHANGES IN TREATED CELLS
• CHAPTER 25. ANTICELLULAR ACTIVITY OF HUMAN INTERFERONS
• CHAPTER 26. THE HUMAN INTERFERONS
• CHAPTER 27. FREE COMMUNICATIONS
• INDEX OF AUTHORS