Cardiac Muscle: The Regulation Of Excitation And Contraction
eBook - PDF

Cardiac Muscle: The Regulation Of Excitation And Contraction

  1. 340 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Cardiac Muscle: The Regulation Of Excitation And Contraction

About this book

Cardiac Muscle: The Regulation of Excitation and Contraction is a 12-chapter text that covers the research studies on characterizing the ionic and molecular mechanisms that regulate excitation and contraction of cardiac muscle. This book describes first the ionic currents underlying diastolic depolarization and pacing of the heart. The discussions then shift to the mechanisms of action of calcium-channel antagonists; the regulation of calcium influx by indigenous factors, such as voltage- or calcium-mediated inactivation; the identification of fixed negative charges on the surface of the sarcolemma; and the regulation of gating and permeability of ion channels by these charges. These topics are followed by examining the molecular and ionic mechanisms that underlie the electrophysiologic actions of adrenergic and cholinergic neurotransmitters and peptide hormones. This text further explores the theoretical and experimental studies of the sodium-calcium exchange process, its stoichiometry, and how the exchanger might contribute to current flow during or after the action potential. Other chapters consider the mechanism of twitch and tonic tension regulation by cardiac glycosides and intracellular sodium and how toxic concentrations induce cardiac arrhythmias. A chapter highlights the identification of sarcolemmal binding sites for calcium, the likelihood that such binding or the release of calcium from the sarcoplasmic reticulum plays a role in the regulation of contraction and the release of calcium from the sarcoplasmic reticulum. The remaining chapters deal with the structural similarities among calcium-binding proteins of the contractile apparatus and the calcium channel, and the regulation of contraction by calcium-binding proteins. Physiologists, pathophysiologists, clinicians, researchers, and students who are interested in heart's function will find this book invaluable.

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Yes, you can access Cardiac Muscle: The Regulation Of Excitation And Contraction by Richard Nathan in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Physiology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Academic Press
Year
2012
Print ISBN
9780125143707
eBook ISBN
9780323155182
Topic
Biological Sciences
Subtopic
Physiology
Index
Biological Sciences

Table of contents

  1. Front Cover
  2. Cardiac Muscle: The Regulation of Excitation and Contraction
  3. Copyright Page
  4. Table of Contents
  5. Contributors
  6. Preface
  7. Chapter 1. Ionic Currents Underlying Cardiac Pacemaker Activity: A Summary of Voltage-Clamp Data from Single Cells
  8. Chapter 2. Inactivation and Modulation of Cardiac Ca Channels
  9. Chapter 3. Negative Surface Charge: Its Identification and Regulation of Cardiac Electrogenesis
  10. Chapter 4. Mechanisms of B-Adrenergic and Cholinergic Control of Ca and K Currents in the Heart
  11. Chapter 5. Modulation of Cell Electrical Properties by Peptide Hormones
  12. Chapter 6. Sodium-Calcium Exchange and Its Role in Generating Electric Current
  13. Chapter 7. Some Experimental Studies of Na-Ca Exchange in Heart Muscle
  14. Chapter 8. The Regulation of Tension in Heart Muscle by Intracellular Sodium
  15. Chapter 9. Cardiac Glycosides: Regulation of Force and Rhythm
  16. Chapter 10. Calcium at the Sarcolemma: Its Role in Control of Myocardial Contraction
  17. Chapter 11. Release of Calcium from the Sarcoplasmic Reticulum
  18. Chapter 12. Calcium-Binding Proteins in the Regulation of Muscle Contraction
  19. Index