Premature Chromosome Condensation

Application in Basic, Clinical, and Mutation Research

P.N. Rao

• Publisher: Academic Press
• Year: 2012
• Print ISBN:
  9780125804509
• eBook ISBN:
  9780323152150
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Premature Chromosome Condensation: Application in Basic, Clinical, and Mutation Research emerged from a workshop supported by the International Union against Cancer that reviewed the status of research on premature chromosome condensation and explored future possibilities, not least in relation to cancer. The workshop was held at the Institut für Humangenetik, Freie Universität Berlin, on September 6, 1980. The book begins with a review of the process of premature chromosome condensation. This is followed by separate chapters on the functional and morphological aspects of premature chromosome condensation; the behavior of prematurely condensed chromosomes (PCC) during mitosis in binucleate and multinucleate cells; chromosomes from spermatogenic cells; and micronucleus-derived PCC. Subsequent chapters discuss the application of banding techniques to the study of PCC; the factors involved in the condensation of interphase chromatin into chromosomes; and the induction of premature chromosome condensation in somatic plant cells. This book will be helpful to readers working in basic and applied research or in teaching. These include cytogeneticists, cell biologists, biochemists, and investigators in the field of mutation research.

Table of contents

• Front Cover
• Premature Chromosome Condensation: Application in Basic, Clinical, and Mutation Research
• Copyright Page
• Table of Contents
• List of Contributors
• Preface
• Chapter 1. The Phenomenon of Premature Chromosome Condensation
• Chapter 2. Cell Cycle and Chromosome Cycle: Morphological and Functional Aspects
• Chapter 3. Spindle Formation and Chromosome Segregation Associated with Premature Chromosome Condensation
• Chapter 4. Prematurely Condensed Chromosomes of Spermatogenic Cells
• Chapter 5. Premature Chromosome Condensation in Micronuclei
• Chapter 6. Banding Patterns in Prematurely Condensed Chromosomes and the Underlying Structure of the Chromosome
• Chapter 7. Cytological Evaluation of Nucleolar Organizing Regions in Prematurely Condensed Chromosomes
• Chapter 8. Cell Cycle Analysis of Temperature-Sensitive Mutants by Premature Chromosome Condensation
• Chapter 9. A Temperature-Sensitive Mutant and the Nature of G2-Mitosis Transition
• Chapter 10. Factors Involved in Prophasing and Telophasing
• Chapter 11. Characterization of Chromosome Condensation Factors of Mammalian Cells
• Chapter 12. Prematurely Condensed Chromosomes and the Analysis of DNA and Chromosome Lesions
• Chapter 13. Premature Chromosome Condensation in the Diagnosis of Malignancies
• Chapter 14. Premature Chromosome Condensation in Plant Cells and Its Potential Use in Genetic Manipulation
• Index