- 305 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
About this book
The Isolated Hepatocyte: Use in Toxicology and Xenobiotic Biotransformations covers the link between research on the isolated hepatocyte and the disciplines of cell culture, toxicology, metabolism, and molecular biology. This book is composed of 11 chapters and begins with an overview of the regulation of liver growth, sulfation, glucuronidation of xenobiotics in specific liver sites. The next chapters deal with toxicology studies in cultured hepatocytes from various species and the in vitro control of hepatocyte proliferation. These topics are followed by discussions of choices and methods of cytotoxicity measures; hepatoxicity of metals; the metabolism and toxicity of xenobiotics in a primary culture; and the mechanism of carcinogen-induced pleiotropic drug resistance in hepatocytes. The concluding chapters describe the in vivo and in vitro measurement of chemically-induced DNA repair in hepatocytes, as well as the genotoxicity studies with human hepatocytes. This book is intended primarily to toxicologists and researchers.
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Information
Topic
MedicineSubtopic
PharmacologyTable of contents
- Front Cover
- The Isolated Hepatocyte: Use in Toxicology and Xenobiotic Biotransformations
- Copyright Page
- Table of Contents
- Preface
- Chapter 1. Regulation of Liver Growth: Historical Perspectives and Future Directions
- Chapter 2. Regulation of Sulfation and Glucuronidation of Xenobiotics in Periportal and Pericentral Regions of the Liver Lobule
- Chapter 3. Toxicology Studies in Cultured Hepatocytes from Various Species
- Chapter 4. Cytochrome P-450-Dependent Monooxygenase Systems in Mouse Hepatocytes
- Chapter 5. Control of Hepatocyte Proliferation in Vitro
- Chapter 6. Cytotoxicity Measures: Choices and Methods
- Chapter 7. Metals, Hepatocytes, and Toxicology
- Chapter 8. The Metabolism and Toxicity of Xenobiotics in a Primary Culture System of Postnatal Rat Hepatocytes
- Chapter 9. The Analysis of Carcinogen-Induced Pleiotropic Drug Resistance in Rat Hepatocytes
- Chapter 10. Measurement of Chemically Induced DNA Repair in Hepatocytes in Vivo and in Vitro As an Indicator of Carcinogenic Potential
- Chapter 11. Genotoxicity Studies with Human Hepatocytes
- Index
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Yes, you can access The Isolated hepatocyte by E.J. Rauckman in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over 1.5 million books available in our catalogue for you to explore.