Time-of-Flight Mass Spectrometry and its Applications

E.W. Schlag

• Publisher: Elsevier Science
• Year: 2012
• Print ISBN:
  9780444818751
• eBook ISBN:
  9780444596185
• Topic: Physical Sciences
• Subtopic: Analytic Chemistry

The resurgence of time-of-flight mass spectrometry (TOF-MS) has had its origin in the simplicity of construction and application of such instruments together with the high transmission and the great increase in resolution that has been achieved. The instrument lends itself naturally to a coupling with pulsed laser sources, though this is not a prerequisite. It also affords a time resolution far beyond that traditionally achieved with mass spectrometric rapid scan techniques - a recent example being the real-time analysis of a multi-component mixture from an automobile exhaust. Furthermore, the mass range appears to be extremely large: mass up to 500 kDa and beyond what is being readily measured in the laboratory today.The present set of contributions attempts to give a survey of current applications from many of the active groups in the field. A variety of new applications are considered which are no doubt just the beginning of large new areas of application. By presenting this work in book form it is hoped that it will be of help to the many groups intending to initiate work in this rapidly expanding new area of mass spectrometry.

Table of contents

• Front Cover
• Time-of-Flight Mass Spectrometry and its Applications
• Copyright Page
• Table of Contents
• Foreword
• Chapter 1. Laser assisted reflectron time-of-flightmass spectrometry
• Chapter 2. How to specify the ion optical system of a time-of-flightmass spectrometer
• Chapter 3. The application of ion optics in time-of-flight massspectrometry
• Chapter 4. Design considerations in energy resolved time-of-flightmass spectrometry
• Chapter 5. Laser ion sources for time-of-flight mass spectrometry
• Chapter 6. Photoemission electron impact ionization intime-of-flight mass spectrometry: an examinationof experimental consequences
• Chapter 7. High-resolution mass spectrometry in a lineartime-of-flight mass spectrometer
• Chapter 8. The design and performance of an ion trap storage-reflectron time-of-flight mass spectrometer
• Chapter 9. Pulse amplitude analysis: a new dimension in single iontime-of-flight mass spectrometry
• Chapter 10. Mass analyzed threshold ionization: structuralinformation for a mass spectrum and mass informationfor ionic spectroscopy
• Chapter 11. Decay energetics of molecular clusters studied bymultiphoton mass spectrometry and pulsed fieldthreshold ionization
• Chapter 12. Using reflectron time-of-flight mass spectrometer techniques to investigate cluster dynamics and bonding
• Chapter 13. The one dimensional photofragment translational spectroscopic technique: intramolecular clocking ofenergy redistribution for molecules falling apartl
• Chapter 14. Quantitative determination of kinetic energy releasesfrom metastable decompositions of sputtered organicions using a time-of-flight mass spectrometer with asingle-stage ion mirror
• Chapter 15. Kinetic energy analysis in time of flight massspectrometry: application of time of flight methods to clusters and pyrolysis studies in supersonic expansions
• Chapter 16. Photodissociation of magnesium ion/molecule complexes in a reflectron time-of-flight mass spectrometer
• Chapter 17. Resonance-enhanced two-photon ionizationtime-of-flight spectroscopy of cold perfluorinated polyethers and their external and internal van der Waals dimers
• Chapter 18. Time of flight mass spectrometry of DNA laser-ablated from frozen aqueous solutions: applications to the Human Genome Project
• Chapter 19. Factors affecting the resolution in matrix-assisted laserdesorption-ionization mass spectrometry
• Chapter 20. Sequencing of peptides in a time-of-flight massspectrometer: evaluation of postsource decay following matrix-assisted laser desorption ionisation (MALDI)
• Chapter 21. Energy-isochronous time-of-flight mass analyzers
• References
• AUTHOR INDEX
• SUBJECT INDEX