Molecular Pathology

The Molecular Basis of Human Disease

William B. Coleman, Gregory J. Tsongalis

• Publisher: Academic Press
• Year: 2017
• eBook ISBN: 9780128027875
• Edition: 2
• Topic: Medicine
• Subtopic: Medical Technology & Supplies

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of "molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of "integrative systems biology - Enhanced digital version included with purchase

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• List of Contributors
• Preface
• Acknowledgments
• Chapter 1. Molecular Mechanisms of Cell Death
• Chapter 2. Acute and Chronic Inflammation Induces Disease Pathogenesis
• Chapter 3. Infection and Host Response
• Chapter 4. Neoplasia
• Chapter 5. Basic Concepts in Human Molecular Genetics
• Chapter 6. The Human Genome: Understanding Human Disease in the Post-Genomic Era
• Chapter 7. The Human Transcriptome: Implications for Understanding, Diagnosing, and Treating Human Disease
• Chapter 8. The Human Epigenome—Implications for the Understanding of Human Disease
• Chapter 9. Clinical Proteomics and Molecular Pathology
• Chapter 10. Integrative Systems Biology
• Chapter 11. Pathology: The Clinical Description of Human Disease
• Chapter 12. Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease
• Chapter 13. Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach
• Chapter 14. Molecular Basis of Cardiovascular Disease
• Chapter 15. Molecular Basis of Hemostatic and Thrombotic Diseases
• Chapter 16. Molecular Basis of Lymphoid and Myeloid Diseases
• Chapter 17. Molecular Basis of Diseases of Immunity
• Chapter 18. Molecular Basis of Pulmonary Disease
• Chapter 19. Molecular Basis of Diseases of the Gastrointestinal Tract
• Chapter 20. Molecular Basis of Liver Disease
• Chapter 21. Molecular Basis of Diseases of the Exocrine Pancreas
• Chapter 22. Molecular Basis of Diseases of the Endocrine System
• Chapter 23. Molecular Basis of Gynecologic Diseases
• Chapter 24. Molecular Basis of Kidney Disease
• Chapter 25. Molecular Pathogenesis of Prostate Cancer
• Chapter 26. Molecular Biology of Breast Cancer
• Chapter 27. Molecular Basis of Skin Disease
• Chapter 28. Molecular Basis of Bone Diseases
• Chapter 29. Molecular Basis of Diseases of the Nervous System
• Chapter 30. Molecular Diagnosis of Human Disease
• Chapter 31. Molecular Assessment of Human Diseases in the Clinical Laboratory
• Chapter 32. Pharmacogenomics and Personalized Medicine in the Treatment of Human Diseases
• Index