Practical Process Research and Development
eBook - PDF

Practical Process Research and Development

  1. 354 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Practical Process Research and Development

About this book

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. - Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" - Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more - Includes over 100 tips for rapid process development - Presents guidelines for implementing and troubleshooting processes

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Yes, you can access Practical Process Research and Development by Neal G. Anderson in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Science Research & Methodology. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Front Cover
  2. Practical Process Research & Development
  3. Contents
  4. Foreword by K. Barry Sharpless
  5. Foreword by Jerome L. Moniot
  6. Preface
  7. About the Author
  8. Chapter 1. Approaches to Process Development
  9. Chapter 2. Route Selection
  10. Chapter 3. Reagent Selection
  11. Chapter 4. Solvent Selection
  12. Chapter 5. Running the Reaction
  13. Chapter 6. Effects of Water
  14. Chapter 7. In-Process Controls
  15. Chapter 8. Optimizing the Reaction by Minimizing Impurities
  16. Chapter 9. Optimizing Catalytic Reactions
  17. Chapter 10. Work-up
  18. Chapter 11. Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying
  19. Chapter 12. Final Product Form and Impurity Considerations
  20. Chapter 13. Vessels and Mixing
  21. Chapter 14. Preparing for and Implementing the Scale-up Run
  22. Chapter 15. Troubleshooting
  23. Chapter 16. Chiral Syntheses
  24. General Index
  25. Reaction Type Index
  26. Reagent Index