Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries

D. Obrecht, J.M. Villalgordo

• Publisher: Pergamon
• Year: 1998
• eBook ISBN:
  9780080517360
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

The words "Combinatorial Chemistry" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand the diversity of structure available to the chemist as well as the access to this diversity, permitting the discovery of new and valuable biological acid material properties. In this outstanding survey of combinatorial organic chemistry, the authors, Obrecht who has established a new combinatorial chemistry company called Polyphor, and Villalgardo have brought together the literature, including that from 1998, and have concisely analysed the applications and achievements of this new field. This work will be of value to all chemists engaged in preparative work, both in industry and academe.

Table of contents

• Front Cover
• Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries
• Copyright Page
• List of Contributors
• Table of Contents
• Foreword
• List of Abbreviations
• Chapter 1. Introduction, Basic Concepts and Strategies
• Chapter 2. Linear Assembly Strategies
• Chapter 3. Library Synthesis in Solution Using Liquid-Liquid and Liquid-Solid Extractions and Polymer-Bound Reagents (CZ, TM, DO)
• Chapter 4. Convergent Assembly Strategies on Solid Supports (JMV)
• Outlook and future directions
• Subject Index
• Acknowledgements