eBook - PDF

Presystemic Drug Elimination

Name: Presystemic Drug Elimination
ISBN: 9781483163604

Butterworths International Medical Reviews: Clinical Pharmacology and Therapeutics

Charles F. George,

David G. Shand,

224 pages
English
PDF
Available on iOS & Android

eBook - PDF

Presystemic Drug Elimination

Butterworths International Medical Reviews: Clinical Pharmacology and Therapeutics

Charles F. George,

David G. Shand,

About this book

Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Section 2 considers the contribution of the liver to presystemic drug elimination, with a particular emphasis on the physiological factors, which determine the rate of breakdown of drugs in vivo. This section also deals with the effects of hepatic cirrhosis on presystemic drug elimination. Section 3 presents first a brief outline of the knowledge of pulmonary structure and relevant physiology, followed by a discussion on "first-pass metabolism of endogenous substrates and drugs across the pulmonary circulation and of environmental chemicals after inhalation. This section also provides the methods for distinguishing between the contribution of the various sites to presystemic drug elimination and the problems associated with attempts to analyze available pharmacokinetic data. This work is an ideal source for clinical pharmacologists and researchers.

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Yes, you can access Presystemic Drug Elimination by Charles F. George,David G. Shand in PDF and/or ePUB format, as well as other popular books in Medicina & Farmacologia. We have over one million books available in our catalogue for you to explore.