Tumor Angiogenesis

Sophia Ran

• Publisher: IntechOpen
• Year: 2012
• Print ISBN: 9789535100096
• eBook ISBN: 9789535167952
• Topic: Medicine
• Subtopic: Oncology

Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.

Table of contents

• Tumor Angiogenesis
• Contents
• Preface
• Chapter 1 Heparin-Like Drugs with Antiangiogenic Activity
• Chapter 2 Regulation of Angiogenesis in Human Cancer via Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)
• Chapter 3 The Effect of Chinese Herb on Tumor Angiogenesis by Inhibiting Vessel Endothelial Cells
• Chapter 4 Beyond VEGF: The NOTCH and ALK1 Signaling Pathways as Tumor Angiogenesis Targets
• Chapter 5 Platelet Regulation of Angiogenesis, Tumor Growth and Metastasis
• Chapter 6 Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature
• Chapter 7 Modeling Tumor Angiogenesis in Zebrafish
• Chapter 8 The Role of VEGF in the Process of Neovasculogenesis
• Chapter 9 Cancer Related Inflammation and Tumor Angiogenesis
• Chapter 10 Infantile Hemangiomas: A Disease Model in the Study of Vascular Development, Aberrant Vasculogenesis and Angiogenesis
• Chapter 11 MicroRNAs Regulation of Tumor Angiogenesis
• Chapter 12 New Molecular Targets for Anti-Angiogenic Therapeutic Strategies
• Chapter 13 Molecular Mechanisms of Tumor Angiogenesis