Current Advances in Amyotrophic Lateral Sclerosis

Alvaro G. Estévez

• Publisher: IntechOpen
• Year: 2013
• Print ISBN: 9789535111955
• eBook ISBN: 9789535171799
• Topic: Medicina
• Subtopic: Neurologia

Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.

Table of contents

• Current Advances in Amyotrophic Lateral Sclerosis
• Contents
• Preface
• Chapter 1 Pathophysiology of Amyotrophic Lateral Sclerosis
• Chapter 2 Multiple Routes of Motor Neuron Degeneration in ALS
• Chapter 3 Genetics of ALS and Correlations Between Genotype and Phenotype in ALS — A Focus on Italian Population
• Chapter 4 The Neuroinflammation in the Physiopathology of Amyotrophic Lateral Sclerosis
• Chapter 5 Superoxide Dismutase and Oxidative Stress in Amyotrophic Lateral Sclerosis
• Chapter 6 The Use of Human Samples to Study Familial and Sporadic Amyotrophic Lateral Sclerosis: New Frontiers and Challenges
• Chapter 7 The Role of the Statistical Method of Motor Unit Number Estimation (MUNE) to Assess the Potential Therapeutic Benefits of Riluzole on Patients with Pre-symptomatic Familial Amyotrophic Lateral Sclerosis
• Chapter 8 Changes in Motor Unit Loss and Axonal Regeneration Rate in Sporadic and Familiar Amyotrophic Lateral Sclerosis (ALS) — Possible Different Pathogenetic Mechanisms?
• Chapter 9 Eye-Gaze Input System Suitable for Use under Natural Light and Its Applications Toward a Support for ALS Patients