Leukemias

Updates and New Insights

Margarita Guenova, Gueorgui Balatzenko, Margarita Guenova, Gueorgui Balatzenko

• Publisher: IntechOpen
• Year: 2015
• Print ISBN:
  9789535122029
• eBook ISBN:
  9789535172635
• Topic: Medicine
• Subtopic: Oncology

Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of leukemias. This in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways in leukemic cells. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options of leukemias requires frequent updating of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research of acute and chronic leukemias with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients with leukemias; on specific clinical scenarios such as pregnancy or age; as well as on some molecular and pathogenetic mechanisms and their respective translation into novel therapies.

Table of contents

• Leukemias - Updates and New Insights
• Contents
• Preface
• Chapter 1 Pediatric High Risk Leukemia — Molecular Insights
• Chapter 2 Early T-cell Precursor Acute Lymphoblastic Leukemia – A Characteristic Neoplasm Presenting the Phenotype of Common Hematopoietic Progenitors for both Myeloid and Lymphoid Lineages
• Chapter 3 Leukemia and Retroviral Disease
• Chapter 4 Gene Mutations in Acute Myeloid Leukemia — Incidence, Prognostic Influence, and Association with Other Molecular Markers
• Chapter 5 Update on Non-M3 Acute Myeloid Leukemia — Etiology, Classification, Risk Stratification, Emergencies, Complications, Disease in Special Circumstances and Current and Future Therapeutics
• Chapter 6 Clofarabine and Adult Acute Myeloid Leukemia
• Chapter 7 Perspective on Therapeutic Strategies of Leukemia Treatment — Focus on Arsenic Compounds
• Chapter 8 New Insights in Prognosis and Therapy of Chronic Lymphocytic Leukaemia
• Chapter 9 Chronic Lymphocytic Leukemia — Microenvironment and B Cells
• Chapter 10 Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
• Chapter 11 Update on Leukemia in Pregnancy